Pyrrolo[2,3-d]pyrimidine compounds

ABSTRACT

A compound of the formula  
                 
 
wherein R 1 , R 2  and R 3  are as defined above, which are inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn&#39;s disease, Alzheimer&#39;s disease, Leukemia and other autoimmune diseases.

BACKGROUND OF THE INVENTION

The present invention relates to pyrrolo[2,3-d]pyrimidine compounds which are inhibitors of protein tyrosine kinases, such as the enzyme Janus Kinase 3 (hereinafter also referred to as JAK3) and as such are useful therapy as immunosuppressive agents for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other indications where immunosuppression would be desirable.

This invention also relates to a method of using such compounds in the treatment of the above indications in mammals, especially humans, and the phamaceutical compositions useful therefor.

JAK3 is a member of the Janus family of protein tyrosine kinases. Although the other members of this family are expressed by essentially all tissues, JAK3 expression is limited to hematopoetic cells. This is consistent with its essential role in signaling through the receptors for IL-2, IL-4, IL-7, IL-9 and IL-15 by non-covalent association of JAK3 with the gamma chain common to these multichain receptors. XSCID patient populations have been identified with severely reduced levels of JAK3 protein or with genetic defects to the common gamma chain, suggesting that immunosuppression should result from blocking signaling through the JAK3 pathway. Animal studies have suggested that JAK3 not only plays a critical role in B and T lymphocyte maturation, but that JAK3 is constitutively required to maintain T cell function. Modulation of immune activity through this novel mechanism can prove useful in the treatment of T cell proliferative disorders such as transplant rejection and autoimmune diseases.

SUMMARY OF THE INVENTION

The present invention relates to a compound of the formula

or the pharmaceutically acceptable salt thereof; wherein

-   -   R¹ is a group of the formula         wherein y is 0, 1 or 2;     -   R⁴ is selected from the group consisting of hydrogen,         (C₁-C₆)alkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl wherein the alkyl,         alkenyl and alkynyl groups are optionally substituted by         deuterium, hydroxy, amino, trifluoromethyl, (C₁-C₄)alkoxy,         (C₁-C₆)acyloxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, cyano,         nitro, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl or (C₁-C₆)acylamino; or R⁴         is (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally         substituted by deuterium, hydroxy, amino, trifluoromethyl,         (C₁-C₆)acyloxy, (C₁-C₆)acylamino, (C₁-C₆)alkylamino,         ((C₁-C₆)alkyl)₂amino, cyano, cyano(C₁-C₆)alkyl,         trifluoromethyl(C₁-C₆)alkyl, nitro, nitro(C₁-C₆)alkyl or         (C₁-C₆)acylamino;     -   R⁵ is selected from the group consisting of         trifluoromethyl(C₁-C₆)alkyl,         (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₃-C₁₀)cycloalkyl         wherein the cycloalkyl group is optionally substituted by one to         five carboxy, cyano, amino, deuterium, hydroxy, (C₁-C₆)alkyl,         (C₁-C₆)alkoxy, halo, (C₁-C₆)acyl, (C₁-C₆)alkylamino,         amino(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—,         (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₁-C₆)alkylamino,         amino(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl,         (C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro,         cyano(C₁-C₆)alkyl, halo(C₁-C₆)alkyl, nitro(C₁-C₆)alkyl,         trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)acylamino,         (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)acylamino,         amino(C₁-C₆)acyl, amino(C₁-C₆)acyl(C₁-C₆)alkyl,         (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl,         R¹⁵R¹⁶N—CO—O—, R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl, (C₁-C₆)alkyl-S(O)_(m),         R¹⁵R¹⁶NS(O)_(m), R¹⁵R¹⁶NS(O)_(m) (C₁-C₆)alkyl, R¹⁵S(O)_(m)R¹⁶N,         R¹⁵S(O)_(m)R¹⁶N(C₁-C₆)alkyl wherein m is 0, 1 or 2 and R¹⁵ and         R¹⁶ are each independently selected from hydrogen or         (C₁-C₆)alkyl; or R⁵ is (C₃-C₁₀)cycloalkyl(C₁-C₆)alkyl,         (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₂-C₆)alkoxy(C₁-C₆)alkyl,         piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl,         (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl,         (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl,         (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl,         (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl,         (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl,         (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl,         (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl,         (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino,         (C₁-C₆)alkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl wherein the alkyl,         alkenyl and alkynyl groups are optionally substituted by one to         five cyano, nitro, halo, deuterium, hydroxy, carboxy,         (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino,         amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or         ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁵ is R¹³CO(C₁-C₆)alkyl or         R¹³CO(C₃-C₁₀)cycloalkyl wherein R¹³ is R²⁰O or R²⁰R²¹N wherein         R²⁰ and R²¹ are each independently selected from the group         consisting of hydrogen, deuterium, (C₁-C₆)alkyl,         (C₆-C₁₀)aryl(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkyl; or R⁵         is R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₃-C₁₀)cycloalkyl wherein R¹⁴ is         (C₂-C₉)heterocycloalkyl, (C₁-C₆)acylpiperazino,         (C₆-C₁₀)arylpiperazino, (C₅-C₉)heteroarylpiperazino,         (C₁-C₆)alkylpiperazino, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino,         (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino,         thiomorpholino, piperidino, pyrrolidino, piperidyl,         (C₁-C₆)alkylpiperidinyl, (C₆-C₁₀)arylpiperidyl,         (C₅-C₉)heteroarylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl,         (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl or (C₁-C₆)acylpiperidyl;     -   or R⁵ is a group of the formula         wherein     -   w is 0, 1 or 2;     -   x is 0, 1, 2 or 3;     -   or R⁵ is a group of the formula         wherein     -   g, h and j are each independently 0 to 3;     -   F, K and P are each independently oxygen, S(O)_(d) wherein d is         0, 1 or 2, NR⁶ or CR⁷R⁸;     -   R⁶ is selected from the group consisting of hydrogen,         (C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl,         (C₁-C₆)alkyl(difluoromethylene),         (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl,         (C₁-C₆)alkoxy(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl,         ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, (C₆-C₁₀)aryl,         (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl,         (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl,         (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl,         (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₂-C₆)alkyl,         (C₁-C₆)acyloxy(C₂-C₆)alkyl, (C₁-C₆)alkoxy(Cr C₆)alkyl,         piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl,         (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl,         (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl,         (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl,         (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl,         (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl,         (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl,         (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl,         (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl,         R¹³CO(C₁-C₆)alkyl wherein R¹³ is R²⁰O or R²⁰R²¹N wherein R²⁰ and         R²¹ are each independently selected from the group consisting of         hydrogen, (C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkyl or         (C₅-C₉)heteroaryl(C₁-C₆)alkyl; or R¹⁴(C₂-C₆)alkyl wherein R¹⁴ is         (C₁-C₆)acylpiperazino, (C₆-C₁₀)arylpiperazino,         (C₅-C₉)heteroarylpiperazino, (C₁-C₆)alkylpiperazino,         (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino,         (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino,         thiomorpholino, piperidino, pyrrolidino, piperidyl,         (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl,         (C₅-C₉)heteroarylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl,         (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl, (C₁-C₆)alkoxyacyl,         (C₁-C₆)alkylaminoaryl, ((C₁-C₆)alkyl₂aminoacyl or         (C₁-C₆)acylpiperidyl;     -   R⁷ and R⁸ are each independently selected from the group         consisting of hydrogen, (C₁-C₆)alkyl, amino, hydroxy,         (C₁-C₆)alkoxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)amino,         (C₁-C₆)acylamino, (C₁-C₆)acyl(C₁-C₆)alkylamino, carboxy,         (C₁-C₆)alkoxyacyl, (C₁-C₆)alkylaminoacyl,         ((C₁-C₆)alkyl)₂aminoacyl, aminoacyl, trifluoromethyl,         trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)alkyl (difluoromethylene),         (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₆-C₁₀)aryl,         (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl,         (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl,         (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl,         (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl,         (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl,         piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl,         piperidyl, (C₁-C₆)alkylpiperidyl,         (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl,         (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl,         (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl,         (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl,         (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl,         (C₁-C₆)alkylsulfonyl(C₁-C₈)alkyl,         (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl,         (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl,         R¹³CO(C₁-C₆)alkyl or R¹³CO(C₃-C₁₀)cycloalkyl wherein R¹³ is R²⁰O         or R²⁰R²¹N wherein R²⁰ and R²¹ are each independently selected         from the group consisting of hydrogen, (C₁-C₆)alkyl,         (C₆-C₁₀)aryl(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkyl; R¹⁴,         R¹⁴(C₁-C₆)alkyl or R¹⁴(C₃-C₁₀)cycloalkyl wherein R¹⁴ is         (C₁-C₆)acylpiperazino, (C₆-C₁₀)arylpiperazino,         (C₅-C₉)heteroarylpiperazino, (C₁-C₆)alkylpiperazino,         (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino,         (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino,         thiomorpholino, piperidino, pyrrolidino, piperidyl,         (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl,         (C₅-C₉)heteroarylpiperidyl, (C₅-C₁₀)aryl(C₁-C₆)alkylpiperidyl,         (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl or (C₁-C₆)acylpiperidyl;         or a group of the formula         wherein p is 0, 1, 2 or 3; and     -   Z is hydroxy, (C₁-C₆)alkoxy or NR¹R² wherein R¹ and R² are each         independently selected from the group consisting of hydrogen,         (C₁-C₆)alkyl, piperidyl, (C₁-C₆)alkylpiperidyl,         (C₅-C₁₀)arylpiperidyl, (C₅-C₉)heteroarylpiperidyl,         (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl,         (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl, (C₁-C₆)acylpiperidyl,         (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl,         (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl,         (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl,         (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, R⁵(C₁-C₆)alkyl,         (C₁-C₅)alkyl(CHR⁵)(C₁-C₆)alkyl wherein R⁵ is hydroxy,         (C₁-C₆)acyloxy, (C₁-C₆)alkoxy, piperazino, (C₁-C₆)acylamino,         (C₁-C₆)alkylthio, (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl,         (C₆-C₁₀)arylsulfinyl, (C₁-C₆)alkylsulfoxyl,         (C₆-C₁₀)arylsulfoxyl, amino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂         amino, (C₁-C₆)acylpiperazino, (C₁-C₆)alkylpiperazino,         (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino,         (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino,         thiomorpholino, piperidino, or pyrrolidino; R⁶(C₁-C₆)alkyl,         (C₁-C₅)alkyl(CHR⁶)(C₁-C₆)alkyl wherein R⁶ is piperidyl,         (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl,         (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroarylpiperidyl or         (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl;     -   or R¹ is defined as OR⁹ or S(O)_(q)R⁹ wherein q is 0, 1 or 2;         and     -   R⁹ is selected from the group consisting of         trifluoromethyl(C₁-C₆)alkyl,         (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₃-C₁₀)cycloalkyl         wherein the cycloalkyl group is optionally substituted by one to         five carboxy, cyano, amino, hydroxy, (C₁-C₆)alkoxy, halo,         (C₁-C₆)alkyl S(O)_(m) wherein m is 0, 1 or 2; R¹⁵R¹⁶NS(O)_(m)         wherein m is 0, 1 or 2 and R¹⁵ and R¹⁶ are each independently         selected from hydrogen or (C₁-C₆)alkyl; (C₁-C₆)acyl,         (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH,         (C₁-C₆)alkylamino-CO—, R¹⁵R⁶N—CO—O—, R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl         wherein R¹⁵ and R¹⁶ are as defined above; (C₂-C₆)alkenyl,         (C₂-C₆)alkynyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl,         hydroxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl,         (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro, cyano(C₁-C₆)alkyl,         nitro(C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl,         (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino,         amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or         ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; (C₂-C₆)alkenyl, (C₂-C₆)alkynyl,         (C₃-C₁₀)cycloalkyl(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl,         (C₂-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl,         (C₁-C₆)acylamino(C₁-C₆)alkyl,         (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl,         (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl,         (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl,         (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl,         (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl,         (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl,         (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl,         (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino,         (C₁-C₆)alkyl wherein the alkyl group is optionally substituted         by one to five cyano, nitro, hydroxy, carboxy, (C₁-C₆)acylamino,         (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl,         (C₁-C₆)alkylamino(C₁-C₆)acyl or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl;         R¹³CO(C₁-C₆)alkyl or R¹³CO(C₃-C₁₀)cycloalkyl wherein R¹³ is R²⁰O         or R²⁰R²¹N wherein R²⁰ and R²¹ are each independently selected         from the group consisting of hydrogen, (C₁-C₆)alkyl,         (C₆-C₁₀)aryl(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkyl; R¹⁴,         R¹⁴(C₁-C₆)alkyl or R(C₃-C₁₀)cycloalkyl wherein R¹⁴ is         (C₂-C₉)heterocycloalkyl, (C₁-C₆)acylpiperazino,         (C₆-C₁₀)arylpiperazino, (C₅-C₉)heteroarylpiperazino,         (C₁-C₆)alkylpiperazino, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino,         (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino,         thiomorpholino, piperidino, pyrrolidino, piperidyl,         (C₁-C₆)alkylpiperidinyl, (C₆-C₁₀)arylpiperidyl,         (C₅-C₉)heteroarylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl,         (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl or (C₁-C₆)acylpiperidyl;     -   or R⁹ is a group of the formula         wherein g, h and j are each independently 0 to 6;     -   F, K and P are each independently oxygen, S(O)d wherein d is 0,         1 or 2, NR⁶ or CR⁷R⁸ wherein R⁶, R⁷ and R⁸ are as defined above;     -   R² and R³ are each independently selected from the group         consisting of hydrogen, deuterium, amino, halo, hydoxy, nitro,         carboxy, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, trifluoromethyl,         trifluoromethoxy, (C₁-C₆)alkyl, (C₁-C₆)alkoxy wherein the alkyl         or alkoxy groups are optionally substittued by one to three         groups selected from halo, hydroxy, carboxy,         amino(C₁-C₆)alkylthio, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino,         (C₅-C₉)heteroaryl, (C₂-C₉)heterocycloalkyl, (C₃-C₉)cycloalkyl or         (C₆-C₁₀)aryl; or R² and R³ are each independently         (C₃-C₁₀)cycloalkyl, (C₃-C₁₀)cycloalkoxy, (C₁-C₆)alkylamino,         ((C₁-C₆)alkyl)₂amino, (C₆-C₁₀)arylamino, (C₁-C₆)alkylthio,         (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl, (C₆-C₁₀)arylsulfinyl,         (C₁-C₆)alkylsulfonyl, (C₆-C₁₀)arylsulfonyl, (C₁-C₆)acyl,         (C₁-C₆)alkoxy-CO—NH—, (C₁-C₆)alkyamino-CO—, (C₅-C₉)heteroaryl,         (C₂-C₉)heterocycloalkyl or (C₆-C₁₀)aryl wherein the heteroaryl,         heterocycloalkyl and aryl groups are optionally substituted by         one to three halo, (C₁-C₆)alkyl, (C₁-C₆)alkyl-CO—NH—,         (C₁-C₆)alkoxy-CO—NH—, (C₁-C₆)alkyl-CO—NH—(C₁-C₆)alkyl,         (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkyl,         (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkoxy, carboxy, carboxy(C₁-C₆)alkyl,         carboxy(C₁-C₆)alkoxy, benzyloxycarbonyl(C₁-C₆)alkoxy,         (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkoxy, (C₆-C₁₀)aryl, amino,         amino(C₁-C₆)alkyl, (C₁-C₆)alkoxycarbonylamino,         (C₆-C₁₀)aryl(C₁-C₆)alkoxycarbonylamino, (C₁-C₆)alkylamino,         ((C₁-C₆)alkyl)₂amino, (C₁-C₆)alkylamino(C₁-C₆)alkyl,         ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, hydroxy, (C₁-C₆)alkoxy,         carboxy, carboxy(C₁-C₆)alkyl, (C₁-C₆)alkoxycarbonyl,         (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH—,         (C₁-C₆)alkyl-CO—NH—, cyano, (C₅-C₉)heterocycloalkyl,         amino-CO—NH—, (C₁-C₆)alkylamino-CO—NH—,         ((C₁-C₆)alkyl)₂amino-CO—NH—, (C₆-C₁₀)arylamino-CO—NH—,         (C₅-C₉)heteroarylamino-CO—NH—,         (C₁-C₆)alkylamino-CO—NH—(C₁-C₆)alkyl,         ((C₁-C₆)alkyl)₂amino-CO—NH—(C₁-C₆)alkyl,         (C₆-C₁₀)arylamino-CO—NH—(C₁-C₆)alkyl,         (C₅-C₉)heteroarylamino-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl,         (C₁-C₆)alkylsulfonylamino,         (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl,         (C₆-C₁₀)arylsulfonylamino,         (C₆-C₁₀)arylsulfonylamino(C₁-C₆)alkyl,         (C₁-C₆)alkylsulfonylamino,         (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₅-C₉)heteroaryl or         (C₂-C₉)heterocycloalkyl;     -   with the proviso that when either R⁴ and R⁵ is hydrogen, the         other of R⁴ or R⁵ cannot be (C₆-C₁₀)aryl or         (C₆-C₁₀)aryl(C₁-C₆)alkyl;     -   with the proviso that when R⁴ is hydrogen, unsubstituted         (C₁-C₆)alkyl or unsubstituted (C₃-C₁₀)Cycloalkyl, R⁵ cannot be         (C₆-C₁₀)aryl(C₁-C₆)alkyl; R²⁰ and R²¹ cannot be         (C₅-C₉)heteroaryl(C₁-C₆)alkyl; and R¹⁴ cannot be         (C₂-C₉)heterocycloalkyl, morpholino, thiomorphlino, piperidino,         pyrrolidino, piperidinyl or (C₁-C₆)alkylpiperidinyl;     -   with the proviso that the sp² and sp carbons of alkenyl or         alkynyl cannot be substituted by hydroxy or amino;     -   with the proviso that when R⁴ is hydrogen, R⁵ cannot be         amino(C₁-C₆)alkyl, (C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl,         ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, furanyl,         (C₁-C₆)alkoxy(C₁-C₆)alkyl or carboxy(C₁-C₆)alkyl;     -   with the proviso that both R⁴ and R⁵ cannot both be         hydroxy(C₁-C₆)alkyl;     -   with the proviso that when R⁴ is (C₁-C₆)alkyl, R⁵ cannot be         (C₁-C₆)alkoxy(C₁-C₆)alkyl or carboxy(C₁-C₆)alkyl; and     -   with the proviso that R¹ cannot be carboxy(C₁-C₆)alkylthio or         (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkylthio.

The present invention also relates to the pharmaceutically acceptable acid addition salts of compounds of the formula I. The acids which are used to prepare the pharmaceutically acceptable acid addition salts of the aforementioned base compounds of this invention are those which form non-toxic acid addition salts, i.e., salts containing pharmacologically acceptable anions, such as the hydrochloride, hydrobromide, hydroiodide, nitrate, sulfate, bisulfate, phosphate, acid phosphate, acetate, lactate, citrate, acid citrate, tartrate, bitartrate, succinate, maleate, fumarate, gluconate, saccharate, benzoate, methanesulfonate, ethanesulfonate, benzenesulfonate, p-toluenesulfonate and pamoate [, 1,1′-methylene-bis-(2-hydroxy-3-naphthoate)]salts.

The invention also relates to base addition salts of formula I. The chemical bases that may be used as reagents to prepare pharmaceutically acceptable base salts of those compounds of formula I that are acidic in nature are those that form non-toxic base salts with such compounds. Such non-toxic base salts include, but are not limited to those derived from such pharmacologically acceptable cations such as alkali metal cations (e.g., potassium and sodium) and alkaline earth metal cations (, calcium and magnesium), ammonium or water-soluble amine addition salts such as N-methylglucamine-(meglumine), and the lower alkanolammonium and other base salts of pharmaceutically acceptable organic amines.

The term “alkyl”, as used herein, unless otherwise indicated, includes saturated monovalent hydrocarbon radicals having straight, branched or cyclic moieties or combinations thereof.

The term “alkoxy”, as used herein, includes O-alkyl groups wherein “alkyl” is defined above.

The term “halo”, as used herein, unless otherwise indicated, includes fluoro, chloro, bromo or iodo.

The compounds of this invention may contain double bonds. When such bonds are present, the compounds of the invention exist as cis and trans configurations and as mixtures thereof.

Unless otherwise indicated, the alkyl and alkenyl groups referred to herein, as well as the alkyl moieties of other groups referred to herein (, alkoxy), may be linear or branched, and they may also be cyclic (e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl) or be linear or branched and contain cyclic moieties. Unless otherwise indicated, halogen includes fluorine, chlorine, bromine, and iodine.

(C₃-C₁₀)Cycloalkyl when used herein refers, to cycloalkyl groups containing zero to two levels of unsaturation such as cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, 1,3-cyclohexadiene, cycloheptyl, cycloheptenyl, bicyclo[3.2.1]octane, norbornanyl etc.

(C₂-C₉)Heterocycloalkyl when used herein refers to pyrrolidinyl, tetrahydrofuranyl, dihydrofuranyl, tetrahydropyranyl, pyranyl, thiopyranyl, aziridinyl, oxiranyl, methylenedioxyl, chromenyl, isoxazolidinyl, 1,3-oxazolidin-3-yl, isothiazolidinyl, 1,3-thiazolidin-3-yl, 1,2-pyrazolidin-2-yl, 1,3-pyrazolidin-1-yl, piperidinyl, thiomorpholinyl, 1,2-tetrahydrothiazin-2-yl, 1,3-tetrahydrothiazin-3-yl, tetrahydrothiadiazinyl, morpholinyl, 1,2-tetrahydrodiazin-2-yl, 1,3-tetrahydrodiazin-1-yl, tetrahydroazepinyl, piperazinyl, chromanyl, etc. One of ordinary skill in the art will understand that the connection of said (C₂-C₉)heterocycloalkyl rings is through a carbon or a sp³ hybridized nitrogen heteroatom.

(C₂-C₉)Heteroaryl when used herein refers to furyl, thienyl, thiazolyl, pyrazolyl, isothiazolyl, oxazolyl, isoxazolyl, pyrrolyl, triazolyl, tetrazolyl, imidazolyl, 1,3,5-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,3-oxadiazolyl, 1,3,5-thiadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, 1,2,4-triazinyl, 1,2,3-triazinyl, 1,3,5-triazinyl, pyrazolo[3,4-b]pyridinyl, cinnolinyl, pteridinyl, purinyl, 6,7-dihydro-5H-[1]pyrindinyl, benzo[b]thiophenyl, 5, 6, 7, 8-tetrahydro-quinolin-3-yl, benzoxazolyl, benzothiazolyl, benzisothiazolyl, benzisoxazolyl, benzimidazolyl, thianaphthenyl, isothianaphthenyl, benzofuranyl, isobenzofuranyl, isoindolyl, indolyl, indolizinyl, indazolyl, isoquinolyl, quinolyl, phthalazinyl, quinoxalinyl, quinazolinyl, benzoxazinyl; etc. One of ordinary skill in the art will understand that the connection of said (C₂-C₉)heterocycloalkyl rings is through a carbon atom or a sp³ hybridized nitrogen heteroatom.

(C₆-C₁₀)aryl when used herein refers to phenyl or naphthyl.

Compounds of formula (I) may be administered in a pharmaceutically acceptable form either alone or in combination with one or more additional agents which modulate a mammalian immune system or with antiinflammatory agents. These agents may include but are not limited to cyclosporin A (e.g. Sandimmune® or Neoral®, rapamycin, FK-506 (tacrolimus), leflunomide, deoxyspergualin, mycophenolate (e.g. Cellcept®), azathioprine (e.g. Imuran®), daclizumab (e.g. Zenapax®. OKT3 (e.g. Orthoclone®), AtGam, aspirin, acetaminophen, ibuprofen, naproxen, piroxicam, and antiinflammatory steroids (e.g. prednisolone or dexamethasone). These agents may be administered as part of the same or separate dosage forms, via the same or different routes of administration, and on the same or different administration schedules according to standard pharmaceutical practice.

The compounds of this invention include all conformational isomers (e.g., cis and trans isomers) and all optical isomers of compounds of the formula I (e.g., enantiomers and diastereomers), as well as racemic, diastereomeric and other mixtures of such isomers.

Preferred compounds of formula I include those wherein R¹ is NR⁴R⁵.

Other preferred compounds of formula I include those wherein R⁴ is hydrogen, (C₁-C₆)alkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by hydroxy, amino, trifluoromethyl, (C₁-C₆)acyloxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino or (C₁-C₆)acylamino; or R⁴ is (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by hydroxy, trifluoromethyl or (C₁-C₆)acyloxy.

Other preferred compounds of formula I include those wherein R⁵ is (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five deuterium, hydroxy, trifluoromethyl, halo, (C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, (C₁-C₆)acylamino, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, halo(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, R¹⁵S(O)_(m)R¹⁶N, R¹⁵S(O)_(m)R¹⁶N(C₁-C₆)alkyl wherein m is 0, 1 or 2 and R¹⁵ and R¹⁶ are each independently selected from hydrogen or (C₁-C₆)alkyl.

Other preferred compounds of formula I include those wherein R² and R³ are each independently selected from the group consisting of hydrogen, halo, (C₁₁-C₆)alkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₁-C₆)alkoxy, (C₃-C₁₀)cycloalkyl, (C₃-C₁₀)cycloalkoxy, (C₂-C₉)heterocycloalkyl, (C₅-C₉)heteroaryl or (C₆-C₁₀)aryl.

Specific preferred compounds of formula I include the following:

-   2-{4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-cyclohexyl}-propan-2-ol; -   2-{3-[(2-Hydroxy-ethyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]4-methyl-cyclohexyl}-propan-2-ol; -   2-[(5-Isopropenyl-2-methyl-cyclohexyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-ethanol; -   (5-Isopropenyl-2-methyl-cyclohexyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,2,2-trifluoroethyl)-amine; -   2-{4-Methyl-3-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(2,2,2-trifluoro-ethyl)-amino]-cyclohexyl}-propan-2-ol; -   2-{4-Methyl-5-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-cyclohex-3-enyl}-propan-2-ol; -   2-[1-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-azetidin-3-yl]-propan-2-ol; -   2-[1-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-azetidin-2-yl]-propan-2-ol; -   (5-Fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(5-isopropenyl-2-methyl-cyclohexyl)-methyl-amine; -   2-{3-[(5-Fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-methyl-amino]4-methyl-cyclohexyl}-propan-2-ol; -   (2-Ethyl-4-isopropenyl-cyclopentyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amine; -   2-{3-Ethyl-4-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-cyclopentyl}-propan-2-ol; -   2-{3-Ethyl-4-[(2-hydroxy-ethyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]cyclopentyl}-propan-2-ol; -   2-[(2-Ethyl-4-isopropenyl-cyclopentyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-ethanol; -   (5-(S)-isopropenyl-2-methyl-cyclohexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine; -   3-Methyl-8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-8-aza-bicyclo[3.2.1]octan-3-ol; -   2-[Cycloheptyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-ethanol; -   2-[Cyclooctyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-ethanol; -   Bicyclo[2.2.1]hept-2-yl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine;     and -   4-Piperidin-1-yl-5-m-tolyl-7H-pyrrolo[2,3-d]pyrimidine.

The present invention also relates to a pharmaceutical composition for (a) treating or preventing a disorder or condition selected from organ transplant rejection, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia, and other autoimmune diseases or (b) the inhibition of protein tyrosine kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising an amount of a compound of formula I or a pharmaceutically acceptable salt thereof, effective in such disorders or conditions and a pharmaceutically acceptable carrier.

The present invention also relates to a pharmaceutical composition for (a) treating or preventing a disorder or condition selected from organ transplant rejection, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia, and other autoimmune diseases or (b) the inhibition of protein tyrosine kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising an amount of a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with T-cell immunosuppressant or antiinflammatory agents, effective in such disorders or conditions and a pharmaceutically acceptable carrier.

The present invention also relates to a method for the inhibition of protein typorosine kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising administering to said mammal an effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof.

The present invention also relates to a method for treating or preventing a disorder or condition selected from organ transplant rejection, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia, and other autoimmune diseases in a mammal, including a human, comprising administering to said mammal an amount of a compound of formula I or a pharmaceutically acceptable salt thereof, effective in treating such a condition.

The present invention also relates to a method for the inhibition of protein typrosine kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising administering to said mammal an effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with T-cell immunosuppressant or antiinflammatory agents.

The present invention also relates to a method for treating or preventing a disorder or condition selected from organ transplant rejection, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia, and other autoimmune diseases in a mammal, including a human, comprising administering to said mammal an amount of a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with T-cell immunosuppressant or antiinflammatory agents, effective in treating such a condition.

DETAILED DESCRIPTION OF THE INVENTION

The following reaction Schemes illustrate the preparation of the compounds of the present invention. Unless otherwise indicated R¹, R², R³ and R⁹ in the reaction Schemes and the discussion that follow are defined as above.

In reaction 1 of Scheme 1, the 4-chloropyrrolo[2,3-d]pyrimidine compound of formula XVII is converted to the corresponding compound of formula XVI, wherein R is benzenesulfonyl or benzyl, by treating XVII with benzenesulfonyl chloride, benzylchloride or benzylbromide in the presence of a base, such as sodium hydride or potassium carbonate, and a polar aprotic solvent, such as dimethylformamide or tetrahydrofuran. The reaction mixture is stirred at a temperature between about 0° C. to about 70° C., preferably about 30° C., for a time period between about 1 hour to about 3 hours, preferably about 2 hours.

In reaction 2 of Scheme 1, the 4-chloropyrrolo[2,3-d]pyrimidine compound of formula XVI is converted to the corresponding 4-aminopyrrolo[2,3-d]pyrimidine compound of formula XV by coupling XVI with an amine of the formula HNR⁴R⁵. The reaction is carried out in an alcohol solvent, such as tert-butanol, methanol or ethanol, or other high boiling organic solvents, such as dimethylformamide, 1,4-dioxane or 1,2-dichloroethane, at a temperature between about 60° C. to about 120° C., preferably about 80° C. Typical reaction times area between about 2 hours to about 48 hours, preferably about 16 hours.

In reaction 3 of Scheme 1, removal of the protecting group from the compound of formula XV, wherein R is benzenesulfonyl, to give the corresponding compound of formula 1, is carried out by treating XV with an alkali base, such as sodium hydroxide or potassium hydroxide, in an alcohol solvent, such as methanol or ethanol, or mixed solvents, such as alcohol/tetrahydrofuran or alcohol/water. The reaction is carried out at room temperature for a time period between about 15 minutes to about 1 hour, preferably 30 minutes. Removal of the protecting group from the compound of formula XV, wherein R is benzyl, is conducted by treating XV with sodium in ammonia at a temperature of about −78° C. for a time period between about 15 minutes to about 1 hour.

In reaction 1 of Scheme 2, the 4-chloropyrrolo[2,3-d]pyrimidine compound of formula XXI, wherein R is hydrogen or benzenesulfonate, is converted to the 4-chloro-5-halopyrrolo[2,3-d]pyrimidine compound of formula XX, wherein Y is chloro, bromo or iodo, by reacting XXI with N-chlorosuccinimide, N-bromosuccinimide or N-iodosuccinimide. The reaction mixture is heated to reflux, in chloroform, for a time period between about 1 hour to about 3 hours, preferably about 1 hour. Alternatively, in reaction 1 of Scheme 2, the 4-chloropyrrolo[2,3-d]pyrimidine of formula XXI, wherein R is hydrogen, is converted to the corresponding 4-chloro-5-nitropyrrolo[2,3-d]pyrimidine of formula XX, wherein Y is nitro, by reacting XXI with nitric acid in sulfuric acid at a temperature between about −10° C. to about 10° C., preferably about 0° C., for a time period between about 5 minutes to about 15 minutes, preferably about 10 minutes. The compound of formula XXI, wherein Y is nitro, is converted to the corresponding 4-chloro-5-aminopyrrolo[2,3-d]pyrimidine of the formula XX, wherein Y is amino, by reacting XXI under a variety of conditions known to one skilled in the art such as palladium hydrogenolysis or tin(IV) chloride and hydrochloric acid.

In reaction 2 of Scheme 2, the 4-chloro-5-halopyrrolo[2,3-d]pyrimidine compound of formula XX, wherein R is hydrogen, is converted to the corresponding compound of formula XIX, wherein R² is (C₁-C₆)alkyl or benzyl, by treating XX with N-butyllithium, at a temperature of about −78° C., and reacting the dianion intermediate so formed with an alkylhalide or benzylhalide at a temperature between about −78° C. to room temperature, preferably room temperature. Alternatively, the dianion so formed is reacted with molecular oxygen to form the corresponding 4-chloro-5-hydroxypyrrolo[2,3-d]pyrimidine compound of formula XIX, wherein R² is hydroxy. The compound of formula XX, wherein Y is bromine or iodine and R is benzenesulfonate, is converted to the compound of formula XIX, wherein R² is (C₆-C₁₂)aryl or vinyl, by treating XX with N-butyllithium, at a temperature of about −78° C., followed by the addition of zinc chloride, at a temperature of about −78° C. The corresponding organo zinc intermediate so formed is then reacted with aryliodide or vinyl iodide in the presence of a catalytic quantity of palladium. The reaction mixture is stirred at a temperature between about 50° C. to about 80° C., preferably about 70° C., for a time period between about 1 hour to about 3 hours, preferably about 1 hour.

In reaction 3 of Scheme 2, the compound of formula XIX is converted to the corresponding compound of formula XVI by treating XIX with N-butyllithium, lithium diisopropylamine or sodium hydride, at a temperature of about −78° C., in the presence of a polar aprotic solvent, such as tetrahydrofuran. The anionic intermediate so formed is further reacted with (a) alkylhalide or benzylhalide, at a temperature between about −78° C. to room temperature, preferably −78 IC, when R³ is alkyl or benzyl; (b) an aldehyde or ketone, at a temperature between about −78° C. to room temperature, preferably −78° C., when R³ is alkoxy; and (c) zinc chloride, at a temperature between about −78° C. to room temperature, preferably −78° C., and the corresponding organozinc intermediate so formed is then reacted with aryliodide or vinyl iodide in the presence of a catalytic quantity of palladium. The resulting reaction mixture is stirred at a temperature between about 50° C. to about 80° C., preferably about 70° C., for a time period between about 1 hour to about 3 hours, preferably about 1 hour. Alternatively, the anion so formed is reacted with molecular oxygen to form the corresponding 4-chloro-6-hydroxypyrrolo[2,3-d]pyrimidine compound of formula XVI, wherein R³ is hydroxy.

In reaction 1 of Scheme 3, the 4-chloropyrrolo[2,3-d]pyrimidine compound of formula XXI is converted to the corresponding compound of formula XXII, according to the procedure described above in reaction 3 of Scheme 2.

In reaction 2 of Scheme 3, the compound of formula XXII is converted to the corresponding compound of formula XVI, according to the procedures described above in reactions 1 and 2 of Scheme 3.

In reaction 1 of Scheme 4, the 4-chloropyrrolo[2,3-d]pyrimidine compound of formula XX is converted to the corresponding 4-aminopyrrolo[2,3-d]pyrimidine compound of formula XXIV, according to the procedure described above in reaction 2 of Scheme 1.

In reaction 2 of Scheme 4, the 4-amino-5-halopyrrolo[2,3-d]pyrimidine compound of formula XXIV, wherein R is benzenesulfonate and Z is bromine or iodine, is converted to the corresponding compound of formula XXIII by reacting XXIV with (a) arylboronic acid, when R² is aryl, in an aprotic solvent, such tetrahydrofuran or dioxane, in the presence of a catalytic quantity of palladium (0) at a temperature between about 50° C. to about 100° C., preferably about 70° C., for a time period between about 2 hours to about 48 hours, preferably about 12 hours; (b)alkynes, when R² is alkynyl, in the presence of a catalytic quantity of copper (I) iodide and palladium (0), and a polar solvent, such as dimethylformamide, at room temperature, for a time period between about 1 hour to about 5 hours, preferably about 3 hours; and (c) alkenes or styrenes, when R² is vinyl or styrenyl, in the presence of a catalytic quantity of palladium in dimethylformamide, dioxane or tetrahydrofuran, at a temperature between about 80° C. to about 100° C., preferably about 100° C., for a time period between about 2 hours to about 48 hours, preferably about 48 hours.

In reaction 3 of Scheme 4, the compound of formula XXIII is converted to the corresponding compound of formula XV, according to the procedure described above in reaction 3 of Scheme 2.

In reaction 1 of Scheme 5, the 4-chloropyrrolo[2,3-d]pyrimidine compound of formula XVII is converted to the corresponding compound of formula XVI, wherein R is defined as above, according to the procedure described above in reaction 1 of Scheme 1.

In reaction 2 of Scheme 5, the 4-chloropyrrolo[2,3-d]pyrimidine compound of formula XVI is converted the to the corresponding compound of formula XXV by coupling XVI with a compound of the formula, R⁹OH, in the presence of sodium hydroxide. The reaction is carried out in a polar aprotic solvent, such as tetrahydrofuran, and heated to reflux for a time period between about 2 hours to about 4 hours, preferably about 3 hours. Removal of the protecting group is carried out according to the procedure described above in reaction 3 of Scheme 1.

In reaction 1 of Scheme 6, the 4-chloropyrrolo[2,3-d]pyrimidine compound of formula XVII is converted to the corresponding compound of formula XXVI by coupling XVII with a compound of the formula, SR⁹, in the presence of potassium tert-butoxide and a polar aprotic solvent, such as tetrahydrofuran. The resulting reaction mixture is heated to reflux for a time period between about 2.5 hours to about 5 hours, preferably about 3.5 hours. The compound of formula XXVI may be further reacted with an oxidizing agent known to one of ordinary skill in the art, such as hydrogen peroxide, oxone, 3-chloroperoxybenzoic acid or tert-butylperoxide to generate the corresponding 4-R⁹ sulfinylpyrrolo[2,3-d]pyrimidine or 4-R⁹ sulfonylpyrrolo compounds.

The compounds of the present invention that are basic in nature are capable of forming a wide variety of different salts with various inorganic and organic acids. Although such salts must be pharmaceutically acceptable for administration to animals, it is often desirable in practice to initially isolate the compound of the present invention from the reaction mixture as a pharmaceutically unacceptable salt and then simply convert the latter back to the free base compound by treatment with an alkaline reagent and subsequently convert the latter free base to a pharmaceutically acceptable acid addition salt. The acid addition salts of the base compounds of this invention are readily prepared by treating the base compound with a substantially equivalent amount of the chosen mineral or organic acid in an aqueous solvent medium or in a suitable organic solvent, such as methanol or ethanol. Upon careful evaporation of the solvent, the desired solid salt is readily obtained. The desired acid salt can also be precipitated from a solution of the free base in an organic solvent by adding to the solution an appropriate mineral or organic acid.

Those compounds of the present invention that are acidic in nature, are capable of forming base salts with various pharmacologically acceptable cations. Examples of such salts include the alkali metal or alkaline-earth metal salts and particularly, the sodium and potassium salts. These salts are all prepared by conventional techniques. The chemical bases which are used as reagents to prepare the pharmaceutically acceptable base salts of this invention are those which form non-toxic base salts with the acidic compounds of the present invention. Such non-toxic base salts include those derived from such pharmacologically acceptable cations as sodium, potassium calcium and magnesium, etc. These salts can easily be prepared by treating the corresponding acidic compounds with an aqueous solution containing the desired pharmacologically acceptable cations, and then evaporating the resulting solution to dryness, preferably under reduced pressure. Alternatively, they may also be prepared by mixing lower alkanolic solutions of the acidic compounds and the desired alkali metal alkoxide together, and then evaporating the resulting solution to dryness in the same manner as before. In either case, stoichiometric quantities of reagents are preferably employed in order to ensure completeness of reaction and maximum yields of the desired final product.

The compositions of the present invention may be formulated in a conventional manner using one or more pharmaceutically acceptable carriers. Thus, the active compounds of the invention may be formulated for oral, buccal, intranasal, parenteral (e.g., intravenous, intramuscular or subcutaneous) or rectal administration or in a form suitable for administration by inhalation or insufflation. The active compounds of the invention may also be formulated for sustained delivery.

For oral administration, the pharmaceutical compositions may take the form of, for example, tablets or capsules prepared by conventional means with pharmaceutically acceptable excipients such as binding agents (e.g., pregelatinized maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose); fillers (e.g., lactose, microcrystalline cellulose or calcium phosphate); lubricants e.g., magnesium stearate, talc or silica); disintegrants (e.g., potato starch or sodium starch glycolate); or wetting agents (e, sodium lauryl sulphate). The tablets may be coated by methods well known in the art. Liquid preparations for oral administration may take the form of, for example, solutions, syrups or suspensions, or they may be presented as a dry product for constitution with water or other suitable vehicle before use. Such liquid preparations may be prepared by conventional means with pharmaceutically acceptable additives such as suspending agents (e.g., sorbitol syrup, methyl cellulose or hydrogenated edible fats); emulsifying agents (I, lecithin or acacia); non-aqueous vehicles (e.g., almond oil, oily esters or ethyl alcohol); and preservatives (e.g., methyl or propyl p-hydroxybenzoates or sorbic acid).

For buccal administration, the composition may take the form of tablets or lozenges formulated in conventional manner.

The active compounds of the invention may be formulated for parenteral administration by injection, including using conventional catheterization techniques or infusion. Formulations for injection may be presented in unit dosage form, e.g., in ampules or in multi-dose containers, with an added preservative. The compositions may take such forms as suspensions, solutions or emulsions in oily or aqueous vehicles, and may contain formulating agents such as suspending, stabilizing and/or dispersing agents. Alternatively, the active ingredient may be in powder form for reconstitution with a suitable vehicle, e.g., sterile pyrogen-free water, before use.

The active compounds of the invention may also be formulated in rectal compositions such as suppositories or retention enemas, e.g., containing conventional suppository bases such as cocoa butter or other glycerides.

For intranasal administration or administration by inhalation, the active compounds of the invention are conveniently delivered in the form of a solution or suspension from a pump spray container that is squeezed or pumped by the patient or as an aerosol spray presentation from a pressurized container or a nebulizer, with the use of a suitable propellant, e.g., dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas. In the case of a pressurized aerosol, the dosage unit may be determined by providing a valve to deliver a metered amount. The pressurized container or nebulizer may contain a solution or suspension of the active compound. Capsules and cartridges (made, for example, from gelatin) for use in an inhaler or insufflator may be formulated containing a powder mix of a compound of the invention and a suitable powder base such as lactose or starch.

A proposed dose of the active compounds of the invention for oral, parenteral or buccal administration to the average adult human for the treatment of the conditions referred to above (e, rheumatoid arthritis) is 0.1 to 1000 mg of the active ingredient per unit dose which could be administered, for example, 1 to 4 times per day.

Aerosol formulations for treatment of the conditions referred to above (e.g., asthma) in the average adult human are preferably arranged so that each metered dose or “puff” of aerosol contains 20 μg to 1000 μg of the compound of the invention. The overall daily dose with an aerosol will be within the range 0.1 mg to 1000 mg. Administration may be several times daily, for example 2, 3, 4 or 8 times, giving for example, 1, 2 or 3 doses each time.

A compound of formula (I) administered in a pharmaceutically acceptable form either alone or in combination with one or more additional agents which modulate a mammlian immune system or with antiinflammatory agents, agents which may include but are not limited to cyclosporin A (e.g. Sandimmune® or Neoral®, rapamycin, FK-506 (tacrolimus), leflunomide, deoxyspergualin, mycophenolate (e.g. Cellcept®, azathioprine (e.g. Imuran®), daclizumab (e.g. Zenapax®), OKT3 (e.g. Orthocolone®), AtGam, aspirin, acctaminophen, ibuprofen, naproxen, piroxicam, and antiinflmmatory steroids (e.g. prednisolone or dexamethasone); and such agents may be administered as part of the same or separate dosage forms, via the same or different routes of administration, and on the same or different administration schedules according to standard pharmaceutical practice.

FK506 (Tacrolimus) is given orally at 0.10-0.15 mg/kg body weight, every 12 hours, within first 48 hours postoperative. Does is monitored by serum Tacrolimus trough levels.

Cyclosporin A (Sandimmune oral or intravenous formulation, or Neoral®, oral solution or capsules) is given orally at 5 mg/kg body weight, every 12 hours within 48 hours postoperative. Dose is monitored by blood Cyclosporin A trough levels.

The active agents can be formulated for sustained delivery according to methods well known to those of ordinary skill in the art. Examples of such formulations can be found in U.S. Pat. Nos. 3,538,214, 4,060,598, 4,173,626, 3,119,742, and 3,492,397.

The ability of the compounds of formula I or their pharmaceutically acceptable salts to inhibit Janus Kinase 3 and, consequently, demonstrate their effectiveness for treating disorders or conditions characterized by Janus Kinase 3 is shown by the following in vitro assay tests.

Biological Assay JAK3 (JH1:GST) Enzymatic Assay

The JAK3 kinase assay utilizes a protein expressed in baculovirus-infected SF9 cells (a fusion protein of GST and the catalytic domain of human JAK3) purified by affinity chromatography on glutathione-Sepaharose. The substrate for the reaction is poly-Glutamic acid-Tyrosine (PGT (4:1), Sigma catalog # P0275), coated onto Nunc Maxi Sorp plates at 100 μg/ml overnight at 37° C. The morning after coating, the plates are washed three times and JAK3 is added to the wells containing 100 μl of kinase buffer (50 mM HEPES, pH 7.3, 125 mM NaCl, 24 mM MgCl2)+0.2 uM ATP+1 mM Na orthovanadate.) The reaction proceeds for 30 minutes at room temperature and the plates is washed three more times. The level of phosphorylated tyrosine in a given well is quantitated by standard ELISA assay utilizing an anti-phosphotyrosine antibody (ICN PY20, cat. #69-151-1).

DND 39/IL4 Cellular Assay for JAK3 Kinase Inhibitors

The DND 39/IL-4 assay is designed to find inhibitors of JAK3 kinase activity which would be prime candidates for immunosupressive and/or allergy. The assay uses a B-cell line called DND39 which has had the luciferase gene driven by the germ line IgE promoter stably integrated into one of the chromosomes. When these cells are stimulated with IL-4, the kinase JAK3, which is associated with the IL4 receptor, phosphorylates the signal transducer STAT6. STAT6 then blinds to the germline IgE promoter and starts transcription of the luciferase gene. Luciferase is measured in a lysate of these cells using the Promega luciferase assay reagent system.

Note: DND39 cells are grown in RPMI 1640 supplemented with 10% heat inactivated FCS, 2 mM L-Glutamine, and 100 units/ml Pen./Strep. The cells are maintained from 1×10⁵ to 1×10⁶ cells/ml. Split to 1×10⁵ on Friday, cells will be at about 1×10⁶ on Monday. Then split 1:2 during the week keeping 200 ml in a flask as needed.

3×10⁵ DND39 cells are plated in 100 μl of RPMI 1640 supplemented with 1% heat inactivated FCS, 2 mM L-glutamine, and 100 units/ml Pen/Step in a 96 well Vee bottom plate (Nunc). Compounds are diluted serially 1:2 in DMSO starting at 4 mM to 1.9 μM. In a 96 well polypropylene plate, changing tips after each dilution. Then 5 μl of each dilution are added to 500 μl of RPMI/1% serum in a 96 tube rack. 125 μL of the compound dilutions are added to the cells and incubated at 37° C., 5% CO₂ for one hour. After one hour, 25 μl of 25 ng/ml IL4 is added to the cells and mixed. Final concentration of IL4 is 2.5 ng/ml and final concentration of compound is from 20 μM to 156 nM. The cells are then incubated overnight 16-18 hours. The plate is then centrifuged at 2500-3000 RPM in a table top centrifuge for 5 minutes. The culture supernatant is carefully removed by aspiration with an 8 well maifold. 100 μl of PBS with calcium and magnesium is added to the pelletted cells. The cells are resuspended in the PBS and transferred to a Packard white OptiPlate. 100 μl of Packard's LucLite reagent is added to the wells of the OptiPlate.

The following Examples illustrate the preparation of the compounds of the present invention but it is not limited to the details thereof. Melting points are uncorrected. NMR data are reported in parts per million (δ) and are referenced to the deuterium lock signal from the sample solvent (deuteriochloroform unless otherwise specified). Commercial reagents were utilized without further purification. THF refers to tetrahydrofuran. DMF refers to N,N-dimethylformamide. Low Resolution Mass Spectra (LRMS) were recorded on either a Hewlett Packard 5989®, utilizing chemical ionization (ammonium), or a Fisons (or Micro Mass) Atmospheric Pressure Chemical Ionization (APCI) platform which uses a 50/50 mixture of acetonitrile/water with 0.1% formic acid as the ionizing agent. Room or ambient temperature refers to 20-25° C.

EXAMPLE 1 Cyclohexyl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine Method A Cyclohexyl-methyl-amine

To a solution of cyclohexanone (98 mg/1 mmol) and acetic acid (120 mg/2 mmol) dissolved in 2.0 mL of 1,2-dichloroethane was added 2.0 mL of a 2 M solution of methylamine in methanol and the resulting mixture stirred at room temperature for 4 h. Polymer supported borohydride (1 g/2.5 mmol) was added and the mixture stirred at room temperature for 1 h then filtered and concentrated to dryness in vacuo affording 66 mg (40%) of the title compound as the acetate salt. H NMR (400 MHz)(CD₃OD) δ: 1.17-1.37 (m, 5H), 1.67 (br d, 1H, J=12.5 Hz), 1.83 (br d, 2H, J=18.7 Hz), 1.86 (s, 3H), 2.04 (br d, 2H, J=10.2 Hz), 2.60 (s, 3H), 2.86-2.92 (m, 1H).

Method B Cyclohexyl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

A mixture of 200 mg (1.30 mmol) of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (prepared by the method of Davoll, J. Am. Chem. Soc., (1960), 82, 131), the product from Method A (589 mg/5.21 mmol) and 3 mL of tert-butanol was stirred in a sealed tube at 100° C. for 24 h. The reaction mixture was added to water, acidified to pH 1 with 1 N HCl (aq), washed twice with diethylether (ether) and basified to pH 14 with 1 N sodium hydroxide (NaOH). The resulting precipitate was filtered and dried in vacuo to obtain 263 mg (88%) of the title compound, mp 177-180° C. ¹H NMR (400 MHz, CDCl₃): δ 1.11-1.22 (m, 1H), 1.43-1.63 (m, 4H), 1.73 (br d, 1H, J=13.3 Hz), 1.83-1.90 (m, 4H), 3.23 (s, 3H), 4.69 (br, 1H), 6.53 (d, 1H, J=3.5 Hz), 7.03 (d, 1H, J=3.5 Hz), 8.30 (s, 1H), 10.6 (br, 1H). LRMS: 231 (M+1).

The title compounds of Examples 2-84 were prepared by a method analogous to that 30′ described in Example 1.

EXAMPLE 2 Benzyl-ethyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Benzylethylamine. Melting Point: 170-172° C.; LRMS: 252.3.

EXAMPLE 3 Methyl-(S)-1-phenyl-ethyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Methyl-(S)-1-phenylethylamine. Melting Point: 131° C.; LRMS: 253.

EXAMPLE 4 Cyclopentyl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cyclopentylmethylamine. LRMS: 217.3.

EXAMPLE 5 Allyl-cyclohexyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Allylcyclohexylamine. LRMS: 257.

EXAMPLE 6 Allyl-cyclopentyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Allylcyclopentylamine. Melting Point: 173-175° C.; LRMS: 243.

EXAMPLE 7 Allyl-cyclopentyl 7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cyclohexylethylamine. LRMS: 245.3.

EXAMPLE 8 (1-Cyclohexyl-ethyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(1-Cyclohexylethyl)methylamine. LRMS: 259.4.

EXAMPLE 9 Cycloheptyl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cycloheptylmethylamine. Melting Point: 177-178° C.; LRMS: 245.3.

EXAMPLE 10 Cyclooctyl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cyclooctyl-methylamine. Melting Point: 188-189° C.; LRMS: 259.4.

EXAMPLE 11 Methyl-(3-methyl-cyclohexyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Methyl-(3-methylcyclohexyl)amine. LRMS: 245.3.

EXAMPLE 12 Methyl-(4-methyl-cyclohexyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Methyl-(4-methylcyclohexyl)-amine. LRMS: 245.3.

EXAMPLE 13 Methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(3,3,5-trimethyl-cyclohexyl)-amine

Methyl-(3,3,5-trimethylcyclohexyl)-amine. LRMS: 273.4.

EXAMPLE 14 Cycloheptyl-ethyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cycloheptylethylamine. Melting Point: 168-169° C.; LRMS: 259.4.

EXAMPLE 15 Cyclooctyl-ethyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cyclooctylethylamine. Melting Point: 155-156° C.; LRMS: 273.4.

EXAMPLE 16 [1-(4-Chloro-phenyl)-propyl]-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

[1-(4-Chlorophenyl)-propyl]methylamine. LRMS: 301.7.

EXAMPLE 17 [2-(2-Methoxy-phenyl)-1-methyl-ethyl]-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

[2-(2-Methoxy-phenyl)-1-methyl-ethyl]-methylamine. LRMS: 297.4.

EXAMPLE 18 (Decahydro-naphthalen-1-yl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Decahydronaphthalen-1-yl-methylamine. LRMS: 285.4.

EXAMPLE 19 Cyclodecyl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cyclodecylmethylamine. LRMS: 287.1.

EXAMPLE 20 Cyclononyl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cyclononylmethyl. LRMS: 273.1.

EXAMPLE 21 2-[Cyclopentyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]ethanol

2-Cyclopentylaminoethanol. Melting Point: 156-158° C.; LRMS: 247.3.

EXAMPLE 22 Cycloheptyl-(2-methoxy-ethyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cycloheptyl-(2-methoxy-ethyl)amine. LRMS: 289.

EXAMPLE 23 Cycloheptyl-cyclopropyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cycloheptyl-cyclopropylamine. LRMS: 271.4.

EXAMPLE 24 Cycloheptyl-cyclopropyl-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-ethanol

Cyclohexylaminoethanol. Melt Point: 200-201° C.; LRMS: 261.3.

EXAMPLE 25 Cyclooctyl-(2-methoxy-ethyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cyclooctyl-(2-methoxy-ethyl)amine. LRMS: 303.

EXAMPLE 26 sec-Butyl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

sec-Butyl-methylamine. Melting Point: 146-148° C.; LRMS: 205.

EXAMPLE 27 2-[Methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-1-phenyl-propan-1-ol

2-Methyl-1-phenyl-propan-1-ol. LRMS: 283, 265.

EXAMPLE 28 [2-(4-Chloro-phenoxy)-1-methyl-ethyl]-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

[2-(4-Chlorophenoxy)-1-methylethyl]-methylamine. Melting Point: 139-141° C.; LRMS: 319, 317, 189.

EXAMPLE 29 N-Cyclohexyl-N′,N′-dimethyl-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-propane-1,3-diamine

N-Cyclohexyl-N′,N′-dimethyl propane-1,3-diamine. LRMS: 302.4.

EXAMPLE 30 N-{2-[Cyclohexyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-ethyl}-acetamide

N-Cyclohexylaminoethyl acetamide. LRMS: 302.4.

EXAMPLE 31 2-[Cycloheptyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-ethanol

2-Cyclohexylaminoethanol. Melting Point: 69-72° C.; LRMS: 275.4.

EXAMPLE 32 2-[Cyclooctyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-ethanol

2-Cyclooctylaminethanol. Melting Point: 66-77° C.; LRMS: 289.4.

EXAMPLE 33 (3,5-Dimethyl-cyclohexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(3,5-Dimethylcyclohexyl)methylamine. LRMS: 259.4.

EXAMPLE 34 2-[Benzyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-ethanol

2-Benzylaminoethanol. LRMS: 269, 251.

EXAMPLE 35 3-[Cyclopentyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-propan-1-ol

3-Cyclopentylamino-propan-1-ol. Melting Point: 162-164° C.; LRMS: 261.3.

EXAMPLE 36 3-[Cycloheptyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-propan-1-ol

3-Cycloheptylaminopropan-1-ol. Melting Point: 62-66° C.; LRMS: 289.4.

EXAMPLE 37 2-[(Decahydro-naphthalen-2-yl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-ethanol

2-Decahydronaphthalen-2-yl-aminoethanol. Melting Point: 75° C.; LRMS: 315.

EXAMPLE 38 2-[(1-Ethyl-propyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-ethanol

2-(1-Ethylpropyl)amine ethanol. Melting Point: 49-53° C.; LRMS: 249.3.

EXAMPLE 39 1-[Cyclohexyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-butan-2-ol

Cyclohexylamino-butan-2-ol. LRMS: 289.

EXAMPLE 40 Bicyclo[2.2.1]hept-2-yl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Bicyclo[2.2.1]hept-2-yl-methylamine. LRMS: 243.

EXAMPLE 41 2(S)-{[Cyclohexyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-methyl}-cyclohexanol

2-(Cyclohexylamine)methylcyclohexanol. LRMS: 329.

EXAMPLE 42 2(R)-{[Cyclohexyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-methyl}-cyclohexanol

2-(Cyclohexylamine)methylcyclohexanol. LRMS: 329.

EXAMPLE 43 (2-Ethyl-cyclopentyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(2-Ethylcyclopentyl)methyl amine. LRMS: 287.

EXAMPLE 44 Cyclononyl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cyclononylmethylamine. LRMS: 273.

EXAMPLE 45 Methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(2,4,4-trimethyl-cyclopentyl)-amine

Methyl-2,4,4-trimethyl-cyclopentyl)-amine. LRMS: 259.

EXAMPLE 46 (3-Ethyl-cyclopentyl)-methyl-(7H-pyrrolo[2,3-d]Pyrimidin-4-yl)-amine

(3-Ethyl-cyclopentyl)methylamine. LRMS: 245.

EXAMPLE 47 (2,5-Dimethyl-cyclohexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(2,5-Dimethylcyclohexyl)methyl-amine. LRMS: 259.

EXAMPLE 48 (3,4-Dimethyl-cyclo hexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin 4-yl)-amine

(3,4-Dimethylcyclohexyl)methylamine. LRMS: 259.

EXAMPLE 49 (4-Isopropyl-cyclohexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(4-Isopropylcyclohexyl)methylamine. LRMS: 273.

EXAMPLE 50 (Decahydro-naphthalen-1-yl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(Decahydronaphthalen-1-yl)methylamine. LRMS: 285.

EXAMPLE 51 (2,2-Dimethyl-cyclohexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(2,2-Dimethylcyclohexyl)methylamine. LRMS: 259.

EXAMPLE 52 (2-Isopropyl-5-methylcyclohexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-amine

(2-Isopropyl-5-methylcyclohexyl)methylamine. LRMS: 287.

EXAMPLE 53 Methyl-(3-methyl-cyclopentyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Methyl-(3-methyl-cyclopentyl)amine. LRMS: 231.

EXAMPLE 54 (1-Benzyl-piperidin-4-yl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(1-Benzylpiperidin-4-yl)methylamine. LRMS: 322.

EXAMPLE 55 (4-tert-Butyl-cyclohexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(4-tert-Butylcyclohexyl)methylamine. LRMS: 287.

EXAMPLE 56 Indan-1-yl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Indan-1-yl-methylamine. LRMS: 265.

EXAMPLE 57 (4-Ethyl-cyclohexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(4-Ethylcyclohexyl)methylamine. LRMS: 259.

EXAMPLE 58 Methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(1,2,3,4-tetrahydro-naphthalen-2-yl)-amine

Methyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine. LRMS: 279.

EXAMPLE 59 Bicyclo[3.2.1]oct-2-yl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Bicyclo[3.2.1]oct-2-yl-methylamine. LRMS: 257.

EXAMPLE 60 Methyl-(octahydro-4,7-methano-inden-5-yl)-(7H-pyrrolo[2,3-d]pyrimidin 4-yl)-amine

Methyl-(octahydro-4,7-methano-inden-5-yl)amine. LRMS: 283.

EXAMPLE 61 Bicyclo[2.2.1]hept-2-yl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Bicyclo[2.2.1]hept-2-yl-methylamine. LRMS: 243.

EXAMPLE 62 (5-Chloro-indan-1-yl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(5-Chloro-indan-1-yl)methylamine. LRMS: 299.

EXAMPLE 63 Adamantan-2-yl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Adamantan-2-yl-methylamine. LRMS: 283.

EXAMPLE 64 (Decahydro-naphthalen-2-yl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(Decahydro-naphthalen-2-yl)methylamine. LRMS: 285.

EXAMPLE 65 (3,5-Dimethyl-cyclohexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(3,5-Dimethylcyclohexyl)methylamine. LRMS: 259.

EXAMPLE 66 Bicyclo[3.3.1]non-9-yl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Bicyclo[3.3.1]non-9-yl-methylamine. LRMS: 271.

EXAMPLE 67 (1-Isopropyl-4-methyl-bicyclo[3.1.0]hex-3-yl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(1-Isopropyl-4-methylbicyclo[3.1.0]hex-3-yl)-methylamine. LRMS: 285.

EXAMPLE 68 Cyclobutyl-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cyclobutylmethylamine. LRMS: 203.

EXAMPLE 69 (2,2-Dimethyl-cyclopentyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(2,2-Dimethyl-cyclopentyl)methylamine. LRMS: 245.

EXAMPLE 70 4-[Methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-cyclohexanecarboxylic Acid Ethyl Ester

4-[Methylamino]cyclohexanecarboxylic acid. LRMS: 303.

EXAMPLE 71 (2-Isopropyl-5-methyl-cyclohexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(2-Isopropyl-5-methyl-cyclohexyl)methylamine. LRMS: 287.

EXAMPLE 72 (3,3-Dimethyl-cyclohexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(3,3-Dimethyl-cyclohexyl)methylamine. LRMS: 259.

EXAMPLE 73 1 (S)-[Cyclohexyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-propan-2-ol

1-[Cyclohexylamino]-propan-2-ol. LRMS: 275.4.

EXAMPLE 74 1(R)-[Cyclohexyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-propan-2-ol

1-[Cyclohexylamino]-propan-2-ol. LRMS: 275.4.

EXAMPLE 75 3-[Cyclohexyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-Propane-1,2-diol

3-[Cyclohexylamino]-propane-1,2-diol. LRMS: 291.4.

EXAMPLE 76 2-[(Decahydro-naphthalen-1-yl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-ethanol

2-[(Decahydro-naphthalen-1-yl)-amino]-ethanol. LRMS: 315.4.

EXAMPLE 77 {2-[Cycloheptyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-ethyl}-carbamic Acid Tert-Butyl Ester

2-[(Cycloheptylamino)ethyl]carbamic acid. LRMS: 374.5.

EXAMPLE 78 Methyl-(3-methyl-cyclohexyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Methyl-(3-methylcyclohexyl)amine. LRMS: 359.4.

EXAMPLE 79 Methyl-(2-methyl-cyclohexyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Methyl-(2-methylcyclohexyl)amine. LRMS: 359.4.

EXAMPLE 80 (2-Ethyl-cyclohexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(2-Ethyl-cyclohexyl)methylamine. LRMS: 373.4.

EXAMPLE 81 Methyl-(2-propyl-cyclohexyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Methyl-(2-propylcyclohexyl)amine. LRMS: 387.4.

EXAMPLE 82 (2,4-Dimethyl-cyclohexyl)-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

(2,4-Dimethylcyclohexyl)methylamine. LRMS: 373.4.

EXAMPLE 83 Methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(2,5,5-trimethyl-cyclohexyl)-amine

Methyl-(2,5,5-trimethylcyclohexyl)-amine. LRMS: 387.4.

EXAMPLE 84 Methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(2,2,5,5-tetramethyl-cyclohexyl)-amine

Methyl-(2,2,5,5-tetramethylcyclohexyl)-amine. LRMS: 401.

EXAMPLE 85 Cyclohexyl-methyl-(6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cyclohexylmethylamine.

Method C 7-Benzenesulfonyl-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

In a flame-dried flask under nitrogen, 780 mg of 60% sodium hydride (19.5 mmol) in mineral oil was added to 30 mL of dimethylformamide (DMF) and the resulting mixture cooled to 0° C. A solution of 2.0 g (13.0 mmol) of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine in 10 mL of DMF was added slowly over a 5 min period. The reaction was stirred for 10 min at which time generation of hydrogen (H₂) ceased. Benzenesulfonylchloride (1.7 mL/13.0 mmol) was added, the reaction warmed to room temperature and stirred for 1 h. Water was added, and the resulting precipitate was filtered and dried in vacuo to obtain 3.4 g (89%) of the title compound as a crystalline solid, mp 163-167° C.

Method D 7-Benzenesulfonyl-4-chloro-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine

In a flame-dried flask under nitrogen, 0.53 mL (3.79 mmol) of diisopropylamine were dissolved in 5 mL of tetrahydrofuran (THF) and the solution cooled to −78° C. n-Butyllithium (3.75 mmol as a 2.5 M solution in hexanes) was added and the resulting mixture brought to 0. ° C. with continued stirring for 10 min. The reaction mixture was again cooled to −78° C. and to this mixture added a solution of 1.0 g (3.40 mmol) of the product from Method C in 10 mL of THF over a 10 min period. The reaction mixture was stirred for 1 h at −78° C., at which time, 8.2 mL (4.10 mmol) of a 0.5 M solution of zinc chloride in THF was added, the reaction mixture was brought to room temperature and stirred for 1 h. Iodobenzene (0.46 mL/4.11 mmol) and a suspension of 197 mg of tetrakis(triphenylphosphine)palladium in 2 mL of THF were added. The resulting mixture was stirred at reflux for 3 h., cooled to room temperature, and partitioned between dichloromethane and water. The aqueous layer was acidified with 1 N HCl and extracted twice with dichloromethane. The dichloromethane layers were combined, washed with 1 N HCl and brine, dried over magnesium sulfate (MgSO₄), filtered and concentrated in vacuo to obtain the title compound. LRMS: 370, 372 (M+2).

Method E 4-Chloro-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine

The product from Method D was dissolved in 10 mL of THF and to this solution was added 5.0 mL of methanol and 1.0 g of NaOH. The reaction mixture was stirred for 15 min., concentrated in vacuo and partitioned between a saturated aqueous solution of ammonium chloride (NH₄Cl) and ethyl acetate. The resulting aqueous layer was extracted twice with ethyl acetate. The ethylacetate layers were combined, washed with brine, dried over MgSO₄, filtered and concentrated in vacuo. The crude product was purified by silica-gel chromatography (1:5 ethyl-acetate/hexane) to obtain 0.59 g (76%) of the title compound as a pale yellow solid, mp 145° C. (dec). LRMS: 230, 232 (M+2).

Method F Cyclohexyl-methyl-(6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

The product from Method E (50 mg/0.218 mmol) was reacted with 0.12 mL of N-methylcyclohexylamine (0.920 mmol) as described in Method B. The reaction mixture was concentrate in vacuo, methanol was added, and the resulting precipitate filtered to provide 7 mg (10%) of the title compound as a yellow solid. ¹H NMR (400 MHz, CDCl₃) δ: 1.18-1.25 (m, 1H), 1.47-1.66 (m, 4H), 1.75-1.90 (m, 5H), 3.30 (s, 3H), 4.74 (br, 1H), 6.79 (s, 1H), 7.32-7.36 (m, 1H), 7.47-7.51 (m, 2H), 7.77 (d, 2H, J=7.9 Hz), 8.33 (s, 1H). LRMS: 307 (M+1).

The title compound of Example 86 was prepared by a method analogous to that described in Example 85.

EXAMPLE 86 (1H-Indol-5-yl)-(6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

1H-Indolamine. LRMS: 326.4.

EXAMPLE 87 Cyclohexyl-methyl-(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Cyclohexylmethylamine.

Method G 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine

To flame-dried flask under N₂ was charged 0.57 ml (4.07 mmol) of diisopropylamine and 5.0 mL of dry THF. The solution was cooled to −78° C. and 1.63 mL (4.08 mmol) of a 2.5 M solution of n-butyllithium in hexanes added. The resulting mixture was brought to 0° C. and stirred for 10 min. After cooling the mixture again to −78° C., a solution of 1.0 g (3.40 mmol) of crude product from Method C in 10 mL of dry THF was added over a 10 min period. The resulting mixture was stirred for 1 h, at which time, 0.28 mL (4.50 mmol) of iodomethane were added. The reaction mixture was stirred for 2 h, quenched with a saturated solution of NH₄Cl and warmed to room temperature. The mixture was stirred for 5 min., diluted with water and extracted three times with ethyl acetate. The combined extracts were washed with brine, dried over MgSO₄, filtered and evaporated in vacuo to obtain the title compound. LRMS: 308, 310 (M+2).

Method H 4-Chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine

The product from Method G was deprotected as described in Method E. The crude product was purified by trituration with hexanes and dichloromethane to obtain 250 mg (44%) of the title compound as a yellow solid. Mp 205° C. dec. LRMS 168, 170 (M+2).

Method I Cyclohexyl-methyl-(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

The product from Method H (50 mg/0.298 mmol) was reacted with 100 mg (0.883 mmol) of N-methylcyclohexylamine as described in Method B. The reaction mixture was worked up as in Method B with the exception that ethyl acetate was used in place of ether. The title compound (42 mg, 58% yield) was obtained as a white solid. Mp 221° C. dec. ¹H NMR (400 MHz, CDCl₃) δ: 1.15-1.25 (m, 1H), 1.43-1.62 (m, 4H), 1.73 (br s, 1H, J=13.7 Hz), 1.82-1.90 (m, 4H), 2.41 (d, 3H, J=0.8 Hz), 3.21 (s, 3H) 4.63 (br s, 1H), 6.20 (s, 1H), 8.22 (s, 1H), 10.1 (br s, 1H). LRMS: 245 (M+1).

The title compound of Example 88 were prepared by a method analogous to that described in Example 87.

EXAMPLE 88 Cyclohexyl-(6-methyl-7H-pyrrolo[2,3-d]Pyrimidin-4-yl)-amine

Cyclohexylamine. LRMS: 231.3.

EXAMPLE 89 4-Cyclohexyloxy-7H-pyrrolo[2,3-d]pyrimidine Method L 7-Benzyl-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

To a stirred solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (250 mg/1.63 mmol) in 12 mL of DMF was added 676 mg (4.89 mmol) of potassium carbonate and the resulting mixture stirred at room temperature for 20 min. Benzylchloride (310 mg/2.45 mmol) was added and the new mixture stirred at room temperature for 24 h then filtered, concentrated and the residue purified by silica gel chromatography (3:1 hexanes/ethyl acetate) affording 318 mg (80%) of the title compound. LRMS: 244.1 (M+1).

Method M 7-Benzyl-4-cyclohexyloxy-7H-pyrrolo[2,3-d]pyrimidine

To a flame dried flask under nitrogen was charged 84 mg (2.10 mmol) of 60% sodium hydride in mineral oil and 3.0 mL of THF and the mixture cooled to 0° C. Cyclohexanol (0.18 mL/0.70 mmol) was added and the reaction mixture stirred for 5 min. A solution of 102 mg (0.419 mmol) of the product from Method L in 1.0 mL of THF was added and the mixture heated to reflux for 3 h. After cooling to room temperature, the reaction mixture was acidified to pH 1 with 2 N HCl and concentrated in vacuo. The resulting residue was then slurried in ethyl acetate, filtered and the filtrate concentrated in vacuo to provide 76 mg (59%) of the title compound as an oil. LRMS: 308 (M+1).

Method N 4-Cyclohexyloxy-7H-pyrrolo[2,3-d]pyrimidine

To liquid ammonia (6.0 mL) at −78° C. was added 33 mg (1.43 mmol) sodium metal and the resulting dark blue solution stirred at −78° C. 10 min. A solution of 75 mg (0.244 mmol) of the product from Method M in 3.0 mL of ether was added dropwise over a 5 min period. The resulting solution stirred at −78° C. for 1 h followed by quenching upon addition of 500 mg of solid ammonium chloride. After evaporation at room temperature, the residual solid was triturated with 25 mL of ethylacetate containing 1 mL of acetic acid for 1 h. Filtration and concetration in vacuo afforded crude material which was purified by preparative thin layer chromatography (silica-gel; 2:1 ethyl acetate/hexanes) to produce 5 mg of the title compound. ¹H NMR (400 MHz) (CDCl₃) δ: 1.27-1.35 (m, 6H), 1.62-1.67 (m, 4H), 5.30-5.36 (m, 1H), 6.55 (d, 1H, J=3.2 Hz), 7.11 (d, 1H, J=3.2 Hz), 8.37 (br s 1H). LRMS: 218.2 (M+1).

EXAMPLE 90 Method O 4-Cyclohexylsulfanyl-7H-pyrrolo[2,3-d]pyrimidine

To a solution of 100 mg (0.651 mmol) of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine dissolved in 3.0 mL of THF was added 0.10 mL (0.818 mmol) of cyclohexylmercaptan and 100 mg (0.847 mmol) of 95% potassium tert-butoxide and the resulting mixture heated at reflux for 3.5 hr. After cooling to room temperature, the reaction mixture was acidified to pH 1 with 2 N HCl and concentrated in vacuo. The residue was then partitioned between ethylacetate and 1 N HCl. The aqueous layer was extracted with ethyl acetate, the ethyl acetate layers were combined, washed with brine, dried over MgSO₄, filtered, and evaporated in vacuo. The cude product was purified by silica-gel chromatography (1:3 ethylacetate/hexanes) providing 34 mg (22%) of the title compound as a white solid. Mp 162-163° C. ¹H NMR (400 MHz) d: 1.22-1.36 (m, 1H), 1.45-1.64 (m, 5H), 1.75-1.79 (m, 2H), 2.12-2.14 (m, 2H), 4.18-4.20 (m, 1H), 6.50 (d, 1H, J=3.7 Hz), 7.19 (d, 1H, J=3.5 Hz), 8.61 (s, 1H), 10.0 (br s, 1H). LRMS: 234 (M+1).

EXAMPLE 91 5-Chloro-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine Method R 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (154 mg, 1.0 mmol) was suspended in 6.0 mL of dry dichloromethane in a flame-dried flask and to this mixture was added N-chlorosuccinimide (147 mg, 1.1 mmol) in one portion. The resulting mixture stirred at room temperature for 18 h, at which time the solvent was removed under reduced pressure. The residue was triturated with water and isolated by filtration to afford 137 mg (72%) of the title compound as a gray solid, mp 224-227° C. (dec). LRMS: 188 (M+1).

Method S 5-Chloro-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine

The product from Method R (57 mg, 0.3 mmol) was suspended in 3.0 mL of tert-butanol and to this solution was added piperidine (90 μL, 0.9 mmol) and the resulting system, heated at reflux for 1 h. The reaction mixture was cooled to room temperature and water was added (4.0 mL). The solution was adjusted to pH 1 with 1 N HCl and then washed with ether. The aqueous layer was removed and adjusted to pH 12 with 2 N NaOH. The solution was then extracted 2×15 mL with dichloromethane and the combined organics washed with water then brine and dried over MgSO₄. Evaporation of solvent afforded 45 mg of a yellow solid that was purified by silica-gel chromatography (3:1 ethyl acetate/hexanes) to yield 23 mg (32%) of the title compound as a light yellow solid. Mp 170-172° C. ¹H NMR (400 MHz, CDCl₃) δ: 1.67-1.74 (m, 6H), 3.65-3.67 (m, 4H), 7.10 (s, 1H), 8.31 (s, 1H). LRMS: 237 (M+1).

The title compounds of Examples 92-94 were prepared by a method analogous to that described in Example 91.

EXAMPLE 92 (5-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(3-ethynyl-phenyl)-amine

3-Ethynylphenyl)amine. Melting Point: 250° C.

EXAMPLE 93 (5-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-cycloheptyl-methyl-amine

Cycloheptylmethylamine. Melting Point: 152-153° C.; LRMS: 279.8.

EXAMPLE 94 (5-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-cyclooctyl-methyl-amine

Cycloooctylmethylamine. Melting Point: 151-153° C.; LRMS: 293.8.

EXAMPLE 95 5-Phenyl-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine Method T 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

To a stirred solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (30 g/0.02 mol) dissolved in 75 mL of chloroform was added 3.5 g (0.02 mol) of N-bromosuccinamide and the resulting mixture refluxed for 1 h. After cooling to room temperature, the precipitate was removed by filtration and dried under reduced pressure affording 4.1 g (89%) of the title compound. ¹H NMR (400 MHz) (CDCl₃) δ: 7.93 (d, 1H, J=2.8 Hz), 8.60 (s, 1H).

Method U 7-Benzenesulfonyl-5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

To a slurry of the product from Method T (4.1 g/0.018 mol) in DMF (15 mL) and cooled to 0° C. was added 1.0 g (0.025 mol) of 60% sodium hydride in mineral oil and the resulting mixture stirred at 0° C. for 15 min. Benzenesulfonyl chloride (3.2 g/0.018 mol) was added, the reaction mixture warmed to room temperature and stirred for 2 h. Water was then added (15 mL) and the resulting solid removed by filtration and dried in vacuo affording 5.9 g (89%) of the title compound.

Method V 7-Benzenesulfonyl-5-bromo-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine

A mixture of 2.0 g (5.37 mmol) of the product from Method U and 1.1 g (13.4 mmol) of piperidine in 10 mL of tert-butanol was heated with stirring at 60° C. for 2 h. After cooling to room temperature, the reaction mixture was partitioned between dichloromethane (25 mL) and water (25 mL). The dichloromethane layer was dried over sodium sulfate (Na₂SO₄) and concentrated to dryness in vacuo affording 2.2 g (97%) of the title compound. ¹H NMR (400 MHz) (CDCl₃) δ: 1.63-1.72 (m, 6H), 3.54-3.57 (m, 4H), 7.53 (t, 2H, J=2.0 Hz), 7.60 (s, 1H), 7.61 (t, 1H, J=2.0 Hz), 8.17-8.20 (m, 2H), 8.43 (s, 1H). LRMS: 422.7, 420.7 (M+1).

Method W 5-Phenyl-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine

To a stirred solution of the product from Method V (100 mg/0.237 mmol) in 1.0 mL of dioxane was added 32 mg (0.261 mmol) of phenylboronic acid and 75 mg (0.356 mmol) of tribasic potassium phosphate followed by 7 mg (0.006 mmol) of tetrakis(triphenylphosphine) palladium. The resulting mixture was degassed with nitrogen and stirred at 100° C. for 48 h. After cooling to room temperature, 1.0 mL of methanol was added followed by 50 mg of NaOH and the new mixture stirred at room temperature for 1 h. The resulting mixture was then partitioned between dichloromethane and water, the dichloromethane layer dried over MgSO₄ and concentrated to dryness in vacuo. The crude product was purified by silica-gel chromatography (2:1 ethyl acetate/hexanes) affording 13 mg (20%) of the title compound. ¹H NMR (400 MHz) (CDCl₃) δ: 1.33-1.34 (m, 4H), 1.43-1.44 (m, 2H), 3.26-3.28 (m, 4H), 7.12 (s, 1H), 7.27 (t, 1H, J=7.2 Hz), 7.38 (t, 2H, J=8.0 Hz), 7.45 (d, 2H, J=0.8 Hz), 8.42 (s, 1H). LRMS: 279.2 (M+1).

The title compounds of Examples 96-99 were prepared by a method analogous to that described in Example 95.

EXAMPLE 96 Cyclohexyl-methyl-(5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amine

Cyclohexylmethylamine. Melting Point: 200° C.; LRMS: 307.4.

EXAMPLE 97 Cyclohexyl-[5-(4-fluoro-Phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-methyl-amine

Cyclohexylmethylamine. Melting Point: 220° C.; LRMS: 325.4.

EXAMPLE 98 Bicyclo[2.2.1]hept-2-yl-(5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Bicyclo[2.2.1]hept-2-yl-amine. LRMS: 305.4.

EXAMPLE 99 [5-(3-Chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-cyclohexyl-methyl-amine

Cyclohexyl-methylamine. LRMS: 455.9.

EXAMPLE 100 Method X 4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

To a stirred solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (54 mg/0.3 mmol) (prepared by the method of Townsend, et. al., J. Am. Chem. Soc., 1969, 91, 2102) suspended in 3.0 mL tert-Butanol was added piperidine (59 μL/0.60 mmol). The resulting mixture was then heated at reflux for 2.5 h and after cooling to room temperature, was transferred to a separatory funnel and diluted with ether (20 mL). The solution was extracted 2×10 mL with 1N HCl, the combined aqueous layers were adjusted to pH 7 with 2 N potassium hydroxide (KOH) solution forming a precipitate which was collected by filtration, washed with water and dried under reduced pressure to give 29 mg (42%) of the title compound as a colorless solid. Mp 209-211° C.; ¹H NMR (400 MHz) (acetone-d6) δ: 1.72-1.74 (m, 6H), 3.72-3.79 (m, 4H), 8.12 (s, 1H), 8.29 (s, 1H). LRMS: 228 (M+1).

EXAMPLE 101 5-Ethynyl-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine Method Y 4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

To a stirred solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (30 g/0.02 mol) dissolved in 80 mL of chloroform was added 4.5 g (0.02 mol) of N-iodosuccinimide and the resulting mixture heated at reflux for 1 h. After cooling to room temperature, the percipitate was removed by flitration and dried under reduced pressure affording 4.6 g (82%) of the title compound.

Method Z 7-Benzenesulfonyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

The title compound was prepared as previously described in Method U using the product from Method X affording 5.4 g (80%) of material. LRMS: 419.6 (M+1), 279.7.

Method AA 7-Benzenesulfonyl-5-iodo-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine

The title compound was prepared by the procedure described in Method V using the product from Method Z to produce the title compound. LRMS: 469 (M+1), 329.1.

Method BB 7-Benzenesulfonyl-4-piperidin-1-yl-5-triethylsilanylethynyl-7H-pyrrolo[2,3-d]pyrimidine

To a flamed-dried flask under nitrogen was charged 211 mg (0.5 mmol) of the product from Method M, 19 mg (0.1 mmol) of copper (I) iodide and 58 mg (0.05 mmol) of tetrakis(triphenylphosphine)palladium. To this mixture was then added 0.14 mL (1.0 mmol) of triethylamine and 0.27 mL (1.5 mmol) of triethylsilylacetylene as a solution in 1.5 mL of dry DMF. The resulting mixture stirred at room temperature for 3 h, at which time, 5.0 mL of water were added and the mixture extracted with ethylacetate. The ethyl acetate extract was dried over MgSO₄ and concentrated in vacuo. The resulting crude product was then purified by silica-gel chromatography (7:1 hexanes/ethyl acetate) affording 194 mg (89%) of the title compound. LRMS 481 (M+1), 341.

Method CC 5-Ethynyl-4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine

To a stirred solution of the product from Method BB (194 mg/0.40 mmol) dissolved in 2.0 mL of dry THF was added dropwise 0.4 mL (0.4 mmol) of a 1 M solution of tetrabutylammonium fluoride in THF. The resulting mixture stirred at room temperature for 10 min, then was transferred to a methanol solution (3.0 mL) containing 1 g. of KOH, the new mixture stirred at room temperature for 15 min. and concentrated in vacuo. The residue was partitioned between water and ethyl acetate, the ethyl acetate layer washed with water and brine, dried over MgSO₄ and concentrated to dryness in vacuo. The crude product was purified by silica-gel chromatography (2:1 ethyl acetate/hexanes) affording 72 mg (64%) of the title compound as a white crystalline solid. Mp 179-181° C. ¹H NMR (400 MHz) (CDCl₃) d: 1.72 (br s, 6H), 3.20 (s, 1H), 3.82-3.83 (m, 4H), 7.47 (s, 1H), 8.35 (s, 1H). LRMS: 227 (M+1). 

1-6. (canceled)
 7. A pharmaceutical composition for (a) treating or preventing a disorder or condition selected from organ transplant rejection, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukemia and other autoimmune diseases or (b) the inhibition of protein tyrosine kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising an amount of a compound of the formula

or the pharmaceutically acceptable salt thereof, wherein R¹ is OR⁹, S(O)_(q)R⁹, or a group of the formula

R² and R³ are each independently hydrogen, deuterium, amino, halo, hydroxy, nitro, carboxy, (C₂-C₆)alkenyl, (C₂₋₆)alkynyl, (C₁-₆)alkyl, or (C₁-C₆)alkoxy wherein the alkyl or alkoxy groups are optionally substituted by one to three groups selected from halo, hydroxy, carboxy, amino(C₁-C₆)alkylthio, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₅-C₉)heteroaryl, (C₂-C₉)heterocycloalkyl, (C₃₋₉)cycloalkyl or (C₆-C₁₀)aryl or R² and R³ are each independently (C₇-C₁₀)cycloalkyl, (C₇-C₁₀)cycloalkoxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₆-C₁₀)arylamino, (C₁-C₆)alkylthio, (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl, (C₆-C₁₀)arylsulfinyl, (C₁-C₆)alkylsulfonyl, (C₆-C₁₀)arylsulfonyl, (C₁-C₆)acyl, (C₁-C₆)alkoxy-CO—NH—, (C₁-C₆)alkylamino-CO—, (C₅-C₉)heteroaryl, (C₂-C₉)heterocycloalkyl or (C₆-C₁₀)aryl wherein the heteroaryl, heterocycloalkyl and aryl groups are optionally substituted by one to three halo, (C₁-C₆)alkyl, (C₁-C₆)alkyl-CO—NH—, (C₁-C₆)alkoxy-CO—NH—, (C₁-₆)alkyl-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkoxy, carboxy, carboxy(C₁-C₆)alkyl, carboxy(C₁-C₆)alkoxy, benzyloxycarbonyl(C₁-C₆)alkoxy, (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkoxy, (C₆-C₁₀)aryl, amino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxycarbonylamino, (C₁-C₆)alkoxycarbonylamino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, hydroxy, (C₁-C₆)alkoxy, (C₁-C₆)alkoxycarbonyl, (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkyl, cyano, amino-CO—NH—, (C₁-C₆)alkylamino-CO—NH—, ((C₁-C₆)alkyl)₂amino-CO—NH—, (C₆-C₁₀)arylamino-CO—NH—, (C₅-C₉)heteroarylamino-CO—NH—, (C₁-C₆)alkylamino-CO—NH—(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino-CO—NH—(C₁-C₆)alkyl, (C₆-C₁₀)arylamino-CO—NH—(C₁-C₆)alkyl, (C₅-C₉)heteroarylamino-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl, (C₁-C₆)alkylsulfonylamino, (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₁-C₆)arylsulfonyl, (C₆-C₁₀)arylsulfonylamino, (C₆-C₁₀)arylsulfonylamino(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonylamino, (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₅-C₉)heteroaryl or (C₂-C₉)heterocycloalkyl; R⁴ is hydrogen, (C₁-C₆)alkyl, (C₂-C₆)alkenyl, or (C₂-C₆)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C₁-C₄)alkoxy, (C₁-C₆)acyloxy, (C₁-C₆)alkylamino, ((C₁-C_)alkyl)₂amino, cyano, nitro, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl or (C₁-C₆)acylamino or R⁴ is (C₇-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C₁-C₆)acyloxy, (C₁-C₆)acylamino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, cyano, cyano(C₁-C₆)alkyl, trifluoromethyl(C₁-C₆)alkyl, nitro, nitro(C₁-C₆)alkyl or (C₁-C₆)acylamino, R⁵ is trifluoromethyl(C₁-C₆)alkyl, (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, or (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C₁-C₆)alkyl, (C₁-C₆)alkoxy, halo, (C₁-C₆)acyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro, cyano(C₁-C₆)alkyl, halo(C₁-C₆)alkyl, nitro(C₁-C₆)alkyl, trifluoromethyl(C₁₋₆)alkyl, (C₁-C₆)acylamino, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, amino(C₁-C₆)acyl(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, R¹⁵R¹⁶N—CO—O—, R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl, (C₁-C₆)alkyl-S(O)_(m), R¹⁵R¹⁶NS(O)_(m), R¹⁵R¹⁶NS(O)_(m) (C₁-C₆)alkyl, R¹⁵S(O)_(m)R¹⁶N, or R¹⁵S(O)_(m)R¹⁶N(C₁-C₆)alkyl; or R⁵ is (C₃-C₁₀)cycloalkyl(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₂-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)alkyl, (C₂-C₆)alkenyl, or (C₂-C₆)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by one to five cyano, nitro, halo, deuterium, hydroxy, carboxy, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁵ is R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or R⁵ is a group of the formula

or R⁵ is a group of the formula

R⁶ is hydrogen, (C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)alkyl(difluoromethylene), (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₁-C₆)alkoxy(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, (C₆-C₁₀)aryl, C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₂-C₆)alkyl, (C₁-C₆)acyloxy(C₂-C₆)alkyl, (C₁-C₆)alkoxy(C₂-₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, R¹³CO(C₁-C₆)alkyl or R¹⁴(C₂-C₆)alkyl; R⁷ and R⁸ are each independently hydrogen, (C₁-C₆)alkyl, amino, hydroxy, (C₁-C₆)alkoxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)amino, (C₁-C₆)acylamino, (C₁-C₆)acyl(C₁-C₆)alkylamino, carboxy, (C₁-C₆)alkoxyacyl, (C₁-C₆)alkylaminoacyl, ((C₁-C₆)alkyl)₂aminoacyl, aminoacyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)alkyl(difluoromethylene), (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁₋₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or a group of the formula

R⁹ is trifluoromethyl(C₁-C₆)alkyl, (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, or (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five carboxy, cyano, amino, hydroxy, (C₁-C₆)alkoxy, halo, (C₁-C₆)alkyl S(O)_(m), R¹⁵R¹⁶NS(O)_(m), (C₁-C₆)acyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—, R¹⁵R¹⁶N—CO—O—, R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro, cyano(C₁-C₆)alkyl, nitro(C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁹ is (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₃-C₁₀)cycloalkyl(C₁-C₆)allyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₂-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino, or (C₁-C₆)alkyl wherein the alkyl group is optionally substituted by one to five cyano, nitro, hydroxy, carboxy, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁹ is R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or R⁹ is a group of the formula

R¹³ is R²⁰O or R²⁰R²¹N; R¹⁴ is (C₂-C₉)heterocycloalkyl, (C₁-C₆)acylpiperazino, (C₆-C₁₀)arylpiperazino, (C₅-C₉)heteroarylpiperazino, (C₁-C₆)alkylpiperazino, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidyl, (C₁-C₆)alkylpiperidinyl, (C₆-C₁₀)arylpiperidyl, (C₅-C₉)heteroarylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl or (C₁-C₆)acylpiperidyl; R¹⁵ and R¹⁶ are each independently hydrogen or (C₁-C₆)alkyl; R¹⁷ and R¹⁸ are each independently hydrogen, (C₁-C₆)alkyl, piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl, (C₅-C₉)heteroarylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl, (C₁-C₆)acylpiperidyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, R²²(C₁-C₆)alkyl, (C₁-C₅)alkyl(CHR²²)(C₁-C₆)alkyl, R²³(C₁-C₆)alkyl, or (C₁-C₅)alkyl(CHR²³)(C₁-C₆)alkyl; R²⁰ and R²¹ are each independently hydrogen, deuterium, (C₁-C₆alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆alkyl; R²² is hydroxy, (C₁-C₆)acyloxy, (C₁-C₆)alkoxy, piperazino, (C₁-C₆)acylamino, (C₁-C₆)alkylthio, (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl, (C₆-C₁₀)arylsulfinyl, (C₁-C₆)alkylsulfoxyl, (C₆-C₁₀)arylsulfoxyl, amino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)acylpiperazino, (C₁-C₆)alkylpiperazino, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino, thiomorpholino, piperidino or pyrrolidino, R²³ is piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroarylpiperidyl or (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl; F, K and P are each independently oxygen, S(O)_(d), NR⁶ or CR⁷R⁸; Z is hydroxy(C₁-C₆)alkoxy or NR¹⁷R¹⁸; d, m, g, w and y are each independently is 0, 1 or 2; g, h and j are each independently 0 to 6; p and x are each independently is 0, 1, 2 or 3: with the proviso that when R⁴ is hydrogen, unsubstituted (C₁-C₆)alkyl or unsubstituted (C₃-C₁₀)cycloalkyl, R⁵ cannot be (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl; and R¹⁴ cannot be (C₂-C₉)heterocycloalkyl, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidinyl or (C₁-C₆)alkylpiperidinyl; with the proviso that the sp² and sp carbons of alkenyl or alkynyl cannot be substituted by hydroxy or amino; with the proviso that when R⁴ is hydrogen, R⁵ cannot be amino(C₁-C₆)alkyl, (C₁-C₆)alkyl, or (C₁-C₆)alkylamino(C₁-C₆)alkyl; with the proviso that both R⁴ and R⁵ cannot both be hydroxy(C₁-C₆)alkyl, and with the proviso that the (C₃-C₁₀)cycloalkyl group of R⁵ contains zero levels of unsaturation, effective in such disorders or conditions and a pharmaceutically acceptable carrier.
 8. A pharmaceutical composition for (a) treating or preventing a disorder or condition selected from organ transplant rejection, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukemia and other autoimmune diseases or (b) the inhibition of protein tyrosine kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising an amount of a compound of the formula

or the pharmaceutically acceptable salt thereof; wherein R¹ is OR⁹, S(O)_(q)R⁹, or a group of the formula

R² and R³ are each independently hydrogen, deuterium, amino, halo, hydroxy, nitro, carboxy, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₁-C₆)alkyl, or (C₁-C₆)alkoxy wherein the alkyl or alkoxy groups are optionally substituted by one to three groups selected from halo, hydroxy, carboxy, amino(C₁-C₆)alkylthio, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₅-C₉)heteroaryl, (C₂-C₉)heterocycloalkyl, (C₃-C₉)cycloalkyl or (C₆-C₁₀)aryl; or R² and R³ are each independently (C₇-C₁₀)cycloalkyl, (C₇-C₁₀)cycloalkoxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₆-C₁₀)arylamino, (C₁-C₆)alkylthio, (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl, (C₆-C₁₀)arylsulfinyl, (C₁-C₆)alkylsulfonyl, (C₆-C₁₀)arylsulfonyl, (C₁-C₆)acyl, (C₁-C₆)alkoxy-CO—NH—, (C₁-C₆)alkylamino-CO—, (C₅-C₉)heteroaryl, (C₂-C₉)heterocycloalkyl or (C₆-C₁₀)aryl wherein the heteroaryl, heterocycloalkyl and aryl groups are optionally substituted by one to three halo, (C₁-C₆)alkyl, (C₁-C₆)alkyl-CO—NH—, (C₁-C₆)alkoxy-CO—NH—, (C₁-C₆)alkyl-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkoxy, carboxy, carboxy(C₁-C₆)alkyl, carboxy(C₁-C₆)alkoxy, benzyloxycarbonyl(C₁-C₆)alkoxy, (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkoxy, (C₆-C₁₀)aryl, amino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxycarbonylamino, (C₆-C₁₀)aryl(C₁-C₆)alkoxycarbonylamino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, hydroxy, (C₁-C₆)alkoxy, (C₁-C₆)alkoxycarbonyl, (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkyl, cyano, amino-CO—NH—, (C₁-C₆)alkylamino-CO—NH—, ((C₁-C₆)alkyl)₂amino-CO—NH—, (C₆-C₁₀)arylamino-CO—NH—, (C₅-C₉)heteroarylamino-CO—NH—, (C₁-C₆)alkylamino-CO—NH—(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino-CO—NH—(C₁-C₆)alkyl, (C₆-C₁₀)arylamino-CO—NH—(C₁-C₆)alkyl, (C₅-C₉)heteroarylamino-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl, (C₁-C₆)alkylsulfonylamino, (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl, (C₆-C₁₀)arylsulfonylamino, (C₆-C₁₀)arylsulfonylamino(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonylamino, (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₅-C₉)heteroaryl or (C₂-C₉)heterocycloalkyl; R⁴ is hydrogen, (C₁-C₆)alkyl, (C₂-C₆)alkenyl, or (C₂-C₆)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C₁-C₄)alkoxy, (C₁-C₆)acyloxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, cyano, nitro, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl or (C₁-C₆)acylamino; or R⁴ is (C₇-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C₁-C₆)acyloxy, (C₁-C₆)acylamino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, cyano, cyano(C₁-C₆)alkyl, trifluoromethyl(C₁-C₆)alkyl, nitro, nitro(C₁-C₆)alkyl or (C₁-C₆)acylamino; R⁵ is trifluoromethyl(C₁-C₆)alkyl, (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, or (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C₁-C₆)alkyl, (C₁-C₆)alkoxy, halo, (C₁-C₆)acyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro, cyano(C₁-C₆)alkyl, halo(C₁-C₆)alkyl, nitro(C₁-C₆)alkyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)acylamino, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, amino(C₁-C₆)acyl(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, R¹⁵R¹⁶N—CO—O—, R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl, (C₁-C₆)alkyl-S(O)_(m), R¹⁵R¹⁶NS(O)_(m), R¹⁵R¹⁶NS(O)_(m) (C₁-C₆)alkyl, R¹⁵S(O)_(m)R¹⁶N, or R¹⁵S(O)_(m)R¹⁶N(C₁-C₆)alkyl; or R⁵ is (C₃-C₁₀)cycloalkyl(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₂-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl(C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)alkyl, (C₂-C₆)alkenyl, or (C₂-C₆)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by one to five cyano, nitro, halo, deuterium, hydroxy, carboxy, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁵ is R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl, or R⁵ is a group of the formula

or R⁵ is a group of the formula

R⁶ is hydrogen, (C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)alkyl(difluoromethylene), (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₁-C₆)alkoxy(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₂-C₆)alkyl, (C₁-C₆)acyloxy(C₂-C₆)alkyl, (C₁-C₆)alkoxy(C₂-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arlsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, R¹³CO(C₁-C₆)alkyl or R¹⁴(C₂-C₆)alkyl, R⁷ and R⁸ are each independently hydrogen, (C₁-C₆)alkyl, amino, hydroxy, (C₁-C₆)alkoxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)amino, (C₁-C₆)acylamino, (C₁-C₆)acyl(C₁-C₆)alkylamino, carboxy, (C₁-C₆)alkoxyacyl, (C₁-C₆)alkylaminoacyl, ((C₁-C₆)alkyl)₂aminoacyl, aminoacyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)alkyl(difluoromethylene), (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arlsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or a group of the formula

R⁹ is trifluoromethyl(C₁-C₆)alkyl, (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, or (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five carboxy, cyano, amino, hydroxy, (C₁-C₆)alkoxy, halo, (C₁-C₆)alkyl S(O)_(m), R¹⁵R¹⁶NS(O)_(m), (C₁-C₆)acyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—, R¹⁵R¹⁶N—CO—O—, R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro, cyano(C₁-C₆)alkyl, nitro(C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁹ is (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₃-C₁₀)cycloalkyl(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₂-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl(C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino, or (C₁-C₆)alkyl wherein the alkyl group is optionally substituted by one to five cyano, nitro, hydroxy, carboxy, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁹ is R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or R⁹ is a group of the formula

R¹³ is R²⁰O or R²⁰R²¹N; R¹⁴ is (C₂-C₉)heterocycloalkyl, (C₁-C₆)acylpiperazino, (C₆-C₁₀)arylpiperazino, (C₅-C₉)heteroarylpiperazino, (C₁-C₆)alkylpiperazino, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidyl, (C₁-C₆)alkylpiperidinyl, (C₆-C₁₀)arylpiperidyl, (C₅-C₉)heteroarylpiperidyl, (C₆-C₁₀)aryl, (C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl or (C₁-C₆)acylpiperidyl; R¹⁵ and R¹⁶ are each independently hydrogen or (C₁-C₆)alkyl; R¹⁷ and R¹⁸ are each independently hydrogen, (C₁-C₆)alkyl, piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl, (C₅-C₉)heteroarylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl, (C₁-C₆)acylpiperidyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, R²²(C₁-C₆)alkyl, (C₁-C₅)alkyl(CHR²²)(C₁-C₆)alkyl, R²³(C₁-C₆)alkyl, or (C₁-C₅)alkyl(CHR²³)(C₁-C₆)alkyl R²⁰ and R²¹ are each independently hydrogen, deuterium, (C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkyl; R²² is hydroxy, (C₁-C₆)acyloxy, (C₁-C₆)alkoxy, piperazino, (C₁-C₆)acylamino, (C₁-C₆)alkylthio, (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl, (C₆-C₁₀)arylsulfinyl, (C₁-C₆)alkylsulfoxyl, (C₆-C₁₀)arylsulfoxyl, amino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)acylpiperazino, (C₁-C₆)alkylpiperazino, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino, thiomorpholino, piperidino or pyrrolidino; R²³ is piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroarylpiperidyl or (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl; F, K and P are each independently oxygen, S(O)_(d), NR⁶ or CR⁷R⁸; Z is hydroxy, (C₁-C₆)alkoxy or NR¹⁷R¹⁸; d, m, q, w, and y are each independently is 0, 1 or 2, g, h and j are each independently 0 to 6, p and x are each independently is 0, 1, 2 or 3, with the proviso that when R⁴ is hydrogen, unsubstituted (C₁-C₆)alkyl or unsubstituted (C₃-C₁₀)cycloalkyl, R⁵ cannot be (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, and R¹⁴ cannot be (C₂-C₉)heterocycloalkyl, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidinyl or (C₁-C₆)alkylpiperidinyl, with the proviso that the sp² and sp carbons of alkenyl or alkynyl cannot be substituted by hydroxy or amino; with the proviso that when R⁴ is hydrogen, R⁵ cannot be amino(C₁-C₆)alkyl, (C₁-C₆)alkyl, or (C₁-C₆)alkylamino(C₁-C₆)alkyl; with the proviso that both R⁴ and R⁵ cannot both be hydroxy(C₁-C₆)alkyl, and with the proviso that the (C₃-C₁₀)cycloalkyl group of R⁵ contains zero levels of unsaturation, alone or in combination with one or more additional agents which modulate a mammalian immune system or with antiinflammatory agents, effective in such disorders or conditions and a pharmaceutically acceptable carrier.
 9. A method for the inhibition of protein tyrosine kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising administering to said mammal an effective amount of a compound of the formula

or the pharmaceutically acceptable salt thereof, wherein R¹ is OR⁹, S(O)R⁹, or a group of the formula

R² and R³ are each independently hydrogen, deuterium, amino, halo, hydroxy, nitro, carboxy, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₁-C₆)alkyl, or (C₁-C₆)alkoxy wherein the alkyl or alkoxy groups are optionally substituted by one to three groups selected from halo, hydroxy, carboxy, amino(C₁-C₆)alkylthio, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₅-C₉)heteroaryl, (C₂-C₉)heterocycloalkyl, (C₃-C₉)cycloalkyl or (C₆-C₁₀)aryl; or R² and R³ are each independently (C₇-C₁₀)cycloalkyl, (C₇-C₁₀)cycloalkoxy(C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₆-C₁₀)arylamino, (C₁-C₆)alkylthio, (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl, (C₆-C₁₀)arylsulfinyl, (C₁-C₆)alkylsulfonyl, (C₆-C₁₀)arylsulfonyl, (C₁-C₆)acyl, (C₁-C₆)alkoxy-CO—NH—, (C₁-C₆)alkylamino-CO—, (C₅-C₉)heteroaryl, (C₂-C₉)heterocycloalkyl or (C₆-C₁₀)aryl wherein the heteroaryl, heterocycloalkyl and aryl groups are optionally substituted by one to three halo, (C₁-C₆)alkyl, (C₁-C₆)alkyl-CO—NH—, (C₁-C₆)alkoxy-CO—NH—, (C₁-C₆)alkyl-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkoxy, carboxy, carboxy(C₁-C₆)alkyl, carboxy(C₁-C₆)alkoxy, benzyloxycarbonyl(C₁-C₆)alkoxy, (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkoxy, (C₆-C₁₀)aryl, amino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxycarbonylamino, (C₆-C₁₀)aryl(C₁-C₆)alkoxycarbonylamino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, hydroxy, (C₁-C₆)alkoxy, (C₁-C₆)alkoxycarbonyl, (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkyl, cyano, amino-CO—NH—, (C₁-C₆)alkylamino-CO—NH—, ((C₁-C₆)alkyl)₂amino-CO—NH—, (C₆-C₁₀)arylamino-CO—NH—, (C₅-C₉)heteroarylamino-CO—NH—, (C₁-C₆)alkylamino-CO—NH—(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino-CO—NH—(C₁-C₆)alkyl, (C₆-C₁₀)arylamino-CO—NH—(C₁-C₆)alkyl, (C₅-C₉)heteroarylamino-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl, (C₁-C₆)alkylsulfonylamino, (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl, (C₆-C₁₀)arylsulfonylamino, (C₆-C₁₀)arylsulfonylamino(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonylamino, (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₅-C₉)heteroaryl or (C₂-C₉)heterocycloalkyl; R⁴ is hydrogen, (C₁-C₆)alkyl, (C₂-C₆)alkenyl, or (C₂-C₆)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C₁-C₄)alkoxy, (C₁-C₆)acyloxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, cyano, nitro, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl or (C₁-C₆)acylamino, or R⁴ is (C₇-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C₁-C₆)acyloxy, (C₁-C₆)acylamino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, cyano, cyano(C₁-C₆)alkyl, trifluoromethyl(C₁-C₆)alkyl, nitro, nitro(C₁-C₆)alkyl or (C₁-C₆)acylamino; R⁵ is trifluoromethyl(C₁-C₆)alkyl, (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, or (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C₁-C₆)alkyl, (C₁-C₆)alkoxy, halo, (C₁-C₆)acyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro, cyano(C₁-C₆)alkyl, halo(C₁-C₆)alkyl, nitro(C₁-C₆)alkyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)acylamino, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, amino(C₁-C₆)acyl(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, R¹⁵R¹⁶N—CO—O—, R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl, (C₁-C₆)alkyl-S(O)_(m), R¹⁵R¹⁶NS(O)_(m), R¹⁵R¹⁶NS(O)_(m) (C₁-C₆)alkyl, R¹⁵S(O)_(m)R¹⁶N or R¹⁵S(O)_(m)R¹⁶N(C₁-C₆)alkyl; or R⁵ is (C₃-C₁₀)cycloalkyl(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₂-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)alkyl, (C₂-C₆)alkenyl, or (C₂-C₆)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by one to five cyano, nitro, halo, deuterium, hydroxy, carboxy, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, or R⁵ is R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or R⁵ is a group of the formula

or R⁵ is a group of the formula

R⁶ is hydrogen, (C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)alkyl(difluoromethylene), (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₁-C₆)alkoxy(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₂-C₆)alkyl, (C₁-C₆)acyloxy(C₂-C₆)alkyl, (C₁-C₆)alkoxy(C₂-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arlsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, R¹³CO(C₁-C₆)alkyl or R¹⁴(C₂-C₆)alkyl; R⁷ and R⁸ are each independently hydrogen, (C₁-C₆)alkyl, amino, hydroxy, (C₁-C₆)alkoxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)amino, (C₁-C₆)acylamino, (C₁-C₆)acyl(C₁-C₆)alkylamino, carboxy, (C₁-C₆)alkoxyacyl, (C₁-C₆)alkylaminoacyl, ((C₁-C₆)alkyl)₂aminoacyl, aminoacyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)alkyl(difluoromethylene), (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, R¹³CO(C₁-C₆)alkyl, R³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or a group of the formula

R⁹ is trifluoromethyl(C₁-C₆)alkyl, (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, or (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five carboxy, cyano, amino, hydroxy, (C₁-C₆)alkoxy, halo, (C₁-C₆)alkyl S(O)_(m), R¹⁵R¹⁶NS(O)_(m), (C₁-C₆)acyl, (C₁-C₆)alkylamino, amino(C₁-C₆alkyl, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—, R¹⁵R¹⁶N—CO—O—, R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro, cyano(C₁-C₆)alkyl, nitro(C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁹ is (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₃-C₁₀)cycloalkyl(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₂-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino, or (C₁-C₆)alkyl wherein the alkyl group is optionally substituted by one to five cyano, nitro, hydroxy, carboxy, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁹ is R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl, or R⁹ is a group of the formula

R¹³ is R²⁰O or R²⁰R²¹N; R¹⁴ is (C₂-C₉)heterocycloalkyl, (C₁-C₆)acylpiperazino, (C₆-C₁₀)arylpiperazino, (C₅-C₉)heteroarylpiperazino, (C₁-C₆)alkylpiperazino, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidyl, (C₁-C₆)alkylpiperidinyl, (C₆-C₁₀)arylpiperidyl, (C₅-C₉)heteroarylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl or (C₁-C₆)acylpiperidyl; R¹⁵ and R¹⁶ are each independently hydrogen or (C₁-C₆)alkyl; R¹⁷ and R¹⁸ are each independently hydrogen, (C₁-C₆)alkyl, piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl, (C₅-C₉)heteroarylpiperidyl(C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl, (C₁-C₆)acylpiperidyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C_(10)aryl(C) ₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, R²²(C₁-C₆)alkyl, (C₁-C₅)alkyl(CHR²²)(C₁-C₆)alkyl, R²³(C₁-C₆)alkyl, or (C₁-C₅)alkyl(CHR²³)(C₁-C₆)alkyl; R²⁰ and R²¹ are each independently hydrogen, deuterium, (C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkyl; R²² is hydroxy, (C₁-C₆)acyloxy, (C₁-C₆)alkoxy, piperazino, (C₁-C₆)acylamino, (C₁-C₆)alkylthio, (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl, (C₆-C₁₀)arylsulfinyl, (C₁-C₆)alkylsulfoxyl(C₆-C₁₀)arylsulfoxyl, amino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)acylpiperazino, (C₁-C₆)alkylpiperazino, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino, thiomorpholino, piperidino or pyrrolidino; R²³ is piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroarylpiperidyl or (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl; F, K and P are each independently oxygen, S(O)_(d), NR⁶ or CR⁷R⁸; Z is hydroxy, (C₁-C₆)alkoxy or NR¹⁷R¹⁸; d, m, g, w, and y are each independently is 0, 1 or 2; g, h and j are each independently 0 to 6; p and x are each independently is 0, 1, 2 or 3; with the proviso that when R⁴ is hydrogen, unsubstituted (C₁-C₆)alkyl or unsubstituted (C₃-C₁₀)cycloalkyl, R⁵ cannot be (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl; and R¹⁴ cannot be (C₂-C₉)heterocycloalkyl, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidinyl or (C₁-C₆)alkylpiperidinyl; with the proviso that the sp² and sp carbons of alkenyl or alkynyl cannot be substituted by hydroxy or amino; with the proviso that when R⁴ is hydrogen, R⁵ cannot be amino(C₁-C₆)alkyl, (C₁-C₆)alkyl, or (C₁-C₆)alkylamino(C₁-C₆)alkyl; with the proviso that both R⁴ and R⁵ cannot both be hydroxy(C₁-C₆)alkyl; and with the proviso that the (C₃-C₁₀)cycloalkyl group of R⁵ contains zero levels of unsaturation.
 10. A method for treating or preventing a disorder or condition selected from organ transplant rejection, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukemia and other autoimmune diseases in a mammal, including a human, comprising administering to said mammal an amount of a compound of the formula

or the pharmaceutically acceptable salt thereof; wherein R¹ is OR⁹, S(O)_(q)R⁹, or a group of the formula

R² and R³ are each independently hydrogen, deuterium, amino, halo, hydroxy, nitro, carboxy, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₁-C₆)alkyl, or (C₁-C₆)alkoxy wherein the alkyl or alkoxy groups are optionally substituted by one to three groups selected from halo, hydroxy, carboxy, amino(C₁-C₆)alkylthio, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₅-C₉)heteroaryl, (C₂-C₉)heterocycloalkyl, (C₃-C₉)cycloalkyl or (C₆-C₁₀)aryl; or R² and R³ are each independently (C₇-C₁₀)cycloalky, (C₇-C₁₀)cycloalkoxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₆-C₁₀)arylamino, (C₁-C₆)alkylthio, (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl, (C₆-C₁₀)arylsulfinyl, (C₁-C₆)alkylsulfonyl, (C₆-C₁₀)arylsulfonyl, (C₁-C₆)acyl, (C₁-C₆)alkoxy-CO—NH—, (C₁-C₆)alkylamino-CO—, (C₅-C₉)heteroaryl, (C₂-C₉)heterocycloalkyl or (C₆-C₁₀)aryl wherein the heteroaryl, heterocycloalkyl and aryl groups are optionally substituted by one to three halo, (C₁-C₆)alkyl, (C₁-C₆)alkyl-CO—NH—, (C₁-C₆)alkoxy-CO—NH—, (C₁-C₆)alkyl-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkoxy, carboxy, carboxy(C₁-C₆)alkyl, carboxy(C₁-C₆)alkoxy, benzyloxycarbonyl(C₁-C₆)alkoxy, (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkoxy, (C₆-C₁₀)aryl, amino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxycarbonylamino, (C₆-C₁₀)aryl(C₁-C₆)alkoxycarbonylamino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, hydroxy, (C₁-C₆)alkoxy, (C₁-C₆)alkoxycarbonyl, (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkyl, cyano, amino-CO—NH—, (C₁-C₆)alkylamino-CO—NH—, ((C₁-C₆)alkyl)₂amino-CO—NH—, (C₆-C₁₀)arylamino-CO—NH—, (C₅-C₉)heteroarylamino-CO—NH—, (C₁-C₆)alkylamino-CO—NH—(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino-CO—NH—(C₁-C₆)alkyl, (C₆-C₁₀)arylamino-CO—NH—(C₁-C₆)alkyl, (C₅-C₉)heteroarylamino-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl, (C₁-C₆)alkylsulfonylamino, (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl, (C₆-C₁₀)arylsulfonylamino, (C₆-C₁₀)arylsulfonylamino(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonylamino, (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₅-C₉)heteroaryl or (C₂-C₉)heterocycloalkyl; R⁴ is hydrogen, (C₁-C₆)alkyl, (C₂-C₆)alkenyl, or (C₂-C₆)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C₁-C₄)alkoxy, (C₁-C₆)acyloxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, cyano, nitro, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl or (C₁-C₆)acylamino; or R⁴ is (C₇-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C₁-C₆)acyloxy, (C₁-C₆)acylamino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, cyano, cyano(C₁-C₆)alkyl, trifluoromethyl(C₁-C₆)alkyl, nitro, nitro(C₁-C₆)alkyl or (C₁-C₆)acylamino; R⁵ is trifluoromethyl(C₁-C₆)alkyl, (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, or (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C₁-C₆)alkyl, (C₁-C₆)alkoxy, halo, (C₁-C₆)acyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro, cyano(C₁-C₆)alkyl, halo(C₁-C₆)alkyl, nitro(C₁-C₆)alkyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)acylamino, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, amino(C₁-C₆)acyl(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, R¹⁵R¹⁶N—CO—O—, R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl, (C₁-C₆)alkyl-S(O)_(m), R¹⁵R¹⁶NS(O)_(m), R¹⁵R¹⁶NS(O)_(m) (C₁-C₆)alkyl, R¹⁵S(O)_(m)R¹⁶N, or R¹⁵S(O)_(m)R¹⁶N(C₁-C₆)alkyl; or R⁵ is (C₃-C₁₀)cycloalkyl(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₂-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)alkyl, (C₂-C₆)alkenyl, or (C₂-C₆)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by one to five cyano, nitro, halo, deuterium, hydroxy, carboxy, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁵ is R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or R⁵ is a group of the formula

or R⁵ is a group of the formula

R⁶ is hydrogen, (C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)alkyl(difluoromethylene), (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₁-C₆)alkoxy(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₂-C₆)alkyl, (C₁-C₆)acyloxy(C₂-C₆)alkyl, (C₁-C₆)alkoxy(C₂-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, R¹³CO(C₁-C₆)alkyl or R¹⁴(C₂-C₆)alkyl; R⁷ and R⁸ are each independently hydrogen, (C₁-C₆)alkyl, amino, hydroxy, (C₁-C₆)alkoxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)amino, (C₁-C₆)acylamino, (C₁-C₆)acyl(C₁-C₆)alkylamino, carboxy, (C₁-C₆)alkoxyacyl, (C₁-C₆)alkylaminoacyl, ((C₁-C₆)alkyl)₂aminoacyl, aminoacyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)alkyl(difluoromethylene), (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or a group of the formula

R⁹ is trifluoromethyl(C₁-C₆)alkyl, (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, or (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five carboxy, cyano, amino, hydroxy, (C₁-C₆)alkoxy, halo, (C₁-C₆)alkyl S(O)_(m), R¹⁵R¹⁶NS(O)_(m), (C₁-C₆)acyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—, R¹⁵R¹⁶N—CO—O—, R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro, cyano(C₁-C₆)alkyl, nitro(C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁹ is (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₃-C₁₀)cycloalkyl(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₂-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino, or (C₁-C₆)alkyl wherein the alkyl group is optionally substituted by one to five cyano, nitro, hydroxy, carboxy, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁹ is R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or R⁹ is a group of the formula

R¹³ is R²⁰O or R²⁰R²¹N; R¹⁴ is (C₂-C₉)heterocycloalkyl, (C₁-C₆)acylpiperazino, (C₆-C₁₀)arylpiperazino, (C₅-C₉)heteroarylpiperazino, (C₁-C₆)alkylpiperazino, (C₆-C_(10)aryl(C) ₁-C₆)alkylpiperazino (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidyl, (C₁-C₆)alkylpiperidinyl, (C₆-C₁₀)arylpiperidyl, (C₅-C₉)heteroarylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl or (C₁-C₆)acylpiperidyl; R¹⁵ and R¹⁶ are each independently hydrogen or (C₁-C₆)alkyl; R¹⁷ and R¹⁸ are each independently hydrogen, (C₁-C₆)alkyl, piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl, (C₅-C₉)heteroarylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl, (C₁-C₆)acylpiperidyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, R²²(C₁-C₆)alkyl, (C₁-C₅)alkyl(CHR²²)(C₁-C₆)alkyl, R²³(C₁-C₆)alkyl, or (C₁-C₅)alkyl(CHR²³)(C₁-C₆)alkyl; R²⁰ and R²¹ are each independently hydrogen, deuterium, (C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkyl; R²² is hydroxy, (C₁-C₆)acyloxy, (C₁-C₆)alkoxy, piperazino, (C₁-C₆)acylamino, (C₁-C₆)alkylthio, (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl, (C₆-C₁₀)arylsulfinyl, (C₁-C₆)alkylsulfoxyl, (C₆-C₁₀)arylsulfoxyl, amino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)acylpiperazino, (C₁-C₆)alkylpiperazino, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino, thiomorpholino, piperidino or pyrrolidino; R²³ is piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroarylpiperidyl or (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl; F, K and P are each independently oxygen, S(O)_(d), NR⁶ or CR⁷R⁸; Z is hydroxy, (C₁-C₆)alkoxy or NR¹⁷R¹⁸; d, m, g, w, and V are each independently is 0, 1 or 2; g, h and j are each independently 0 to 6; p and x are each independently is 0, 1, 2 or 3; with the proviso that when R⁴ is hydrogen, unsubstituted (C₁-C₆)alkyl or unsubstituted (C₃-C₁₀)cycloalkyl, R⁵ cannot be (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl; and R¹⁴ cannot be (C₂-C₉)heterocycloalkyl, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidinyl or (C₁-C₆)alkylpiperidinyl; with the proviso that the sp² and sp carbons of alkenyl or alkynyl cannot be substituted by hydroxy or amino; with the proviso that when R⁴ is hydrogen, R⁵ cannot be amino(C₁-C₆)alkyl, (C₁-C₆)alkyl, or (C₁-C₆)alkylamino(C₁-C₆)alkyl; with the proviso that both R⁴ and R⁵ cannot both be hydroxy(C₁-C₆)alkyl; and with the proviso that the (C₃-C₁₀)cycloalkyl group of R⁵ contains zero levels of unsaturation, effective in treating or preventing such disorders or conditions.
 11. A method for the inhibition of protein tyrosine kinases or Janus Kinase 3 (JAK3) in a mammal, including a human, comprising administering to said mammal an effective amount of a compound of the formula

or the pharmaceutically acceptable salt thereof, wherein R¹ is OR⁹, S(O)_(q)R⁹, or a group of the formula

R² and R³ are each independently hydrogen, deuterium, amino, halo, hydroxy, nitro, carboxy, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₁-C₆)alkyl, or (C₁-C₆)alkoxy wherein the alkyl or alkoxy groups are optionally substituted by one to three groups selected from halo, hydroxy, carboxy, amino(C₁-C₆)alkylthio, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₅-C₉)heteroaryl, (C₂-C₉)heterocycloalkyl, (C₃-C₉)cycloalkyl or (C₆-C₁₀)aryl; or R² and R³ are each independently (C₇-C₁₀)cycloalkyl, (C₇-C₁₀)cycloalkoxy(C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₆-C₁₀)arylamino, (C₁-C₆)alkylthio, (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl, (C₆-C₁₀)arylsulfinyl, (C₁-C₆)alkylsulfonyl, (C₆-C₁₀)arylsulfonyl, (C₁-C₆)acyl, (C₁-C₆)alkoxy-CO—NH—, (C₁-C₆)alkylamino-CO—, (C₅-C₉)heteroaryl, (C₂-C₉)heterocycloalkyl or (C₆-C₁₀)aryl wherein the heteroaryl, heterocycloalkyl and aryl groups are optionally substituted by one to three halo, (C₁-C₆)alkyl, (C₁-C₆)alkyl-CO—NH—, (C₁-C₆)alkoxy-CO—NH—, (C₁-C₆)alkyl-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkoxy, carboxy, carboxy(C₁-C₆)alkyl, carboxy(C₁-C₆)alkoxy, benzyloxycarbonyl(C₁-C₆)alkoxy, (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkoxy, (C₆-C₁₀)aryl, amino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxycarbonylamino, (C₆-C₁₀)aryl(C₁-C₆)alkoxycarbonylamino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, hydroxy, (C₁-C₆)alkoxy, (C₁-C₆)alkoxycarbonyl, (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkyl, cyano, amino-CO—NH—, (C₁-C₆)alkylamino-CO—NH—, ((C₁-C₆)alkyl)₂amino-CO—NH—, (C₆-C₁₀)arylamino-CO—NH—, (C₅-C₉)heteroarylamino-CO—NH—, (C₁-C₆)alkylamino-CO—NH—(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino-CO—NH—(C₁-C₆)alkyl, (C₆-C₁₀)arylamino-CO—NH—(C₁-C₆)alkyl, (C₅-C₉)heteroarylamino-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl, (C₁-C₆)alkylsulfonylamino, (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl, (C₆-C₁₀)sulfonylamino(C₆-C₁₀)arylsulfonylamino(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonylamino, (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₅-C₉)heteroaryl or (C₂-C₉)heterocycloalkyl; R⁴ is hydrogen, (C₁-C₆)alkyl, (C₁-C₆)alkenyl, or (C₂-C₆)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C₁-C₄)alkoxy, (C₁-C₆)acyloxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, cyano, nitro, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl or (C₁-C₆)acylamino; or R⁴ is (C₇-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C₁-C₆)acyloxy, (C₁-C₆)acylamino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, cyano, cyano(C₁-C₆)alkyl, trifluoromethyl(C₁-C₆)alkyl, nitro, nitro(C₁-C₆)alkyl or (C₁-C₆)acylamino; R⁵ is trifluoromethyl(C₁-C₆)alkyl, (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, or (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C₁-C₆)alkyl, (C₁-C₆)alkoxy, halo, (C₁-C₆)acyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro, cyano(C₁-C₆)alkyl, halo(C₁-C₆)alkyl, nitro(C₁-C₆)alkyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)acylamino, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, amino(C₁-C₆)acyl(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, R¹⁵R¹⁶N—CO—O—, R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl, (C₁-C₆)alkyl-S(O)_(m), R¹⁵R¹⁶NS(O)_(m), R¹⁵R¹⁶NS(O)_(m) (C₁-C₆)alkyl, R¹⁵S(O)_(m), R¹⁶N, or R¹⁵S(O)_(m)R¹⁶N(C₁-C₆)alkyl; or R⁵ is (C₃-C₁₀)cycloalkyl(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₂-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₆-C₁)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)alkyl, (C₂-C₆)alkenyl, or (C₂-C₆)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by one to five cyano, nitro, halo, deuterium, hydroxy, carboxy, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or ((C₁-C₆)alkyl)_amino(C₁-C₆)acyl; or R⁵ is R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or R⁵ is a group of the formula

or R⁵ is a group of the formula

R⁶ is hydrogen, (C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)alkyl(difluoromethylene), (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₁-C₆)alkoxy(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₂-C₆)alkyl, (C₁-C₆)acyloxy(C₂-C₆)alkyl, (C₁-C₆)alkoxy(C₂-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, R¹³CO(C₁-C₆)alkyl or R¹⁴(C₂-C₆)alkyl; R⁷ and R⁸ are each independently hydrogen, (C₁-C₆)alkyl, amino, hydroxy, (C₁-C₆)alkoxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)amino, (C₁-C₆)acylamino, (C₁-C₆)acyl(C₁-C₆)alkylamino, carboxy, (C₁-C₆)alkoxyacyl, (C₁-C₆)alkylaminoacyl, ((C₁-C₆)alkyl)₂aminoacyl, aminoacyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)alkyl(difluoromethylene), (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C_)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl, or a group of the formula

R⁹ is trifluoromethyl(C₁-C₆)alkyl, (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, or (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five carboxy, cyano, amino, hydroxy, (C₁-C₆)alkoxy, halo, (C₁-C₆)alkyl S(O)_(m), R¹⁵R¹⁶NS(O)_(m), (C₁-C₆)acyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—, R¹⁵R¹⁶N—CO—O—, R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro, cyano(C₁-C₆)alkyl, nitro(C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, or R⁹ is (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₃-C₁₀)cycloalkyl(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₂-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino, or (C₁-C₆)alkyl wherein the alkyl group is optionally substituted by one to five cyano, nitro, hydroxy, carboxy, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁹ is R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or R⁹ is a group of the formula

R¹³ is R²⁰O or R²⁰R²¹N; R¹⁴ is (C₂-C₉)heterocycloalkyl, (C₁-C₆)acylpiperazino, (C₆-C₁₀)arylpiperazino, (C₅-C₉)heteroarylpiperazino, (C₁-C₆)alkylpiperazino, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidyl, (C₁-C₆)alkylpiperidinyl, (C₆-C₁₀)arylpiperidyl, (C₅-C₉)heteroarylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl or (C₁-C₆)acylpiperidyl; R¹⁵ and R¹⁶ are each independently hydrogen or (C₁-C₆)alkyl; R¹⁷ and R¹⁸ are each independently hydrogen, (C₁-C₆)alkyl, piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl, (C₅-C₉)heteroarylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl, (C₁-C₆)acylpiperidyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, R²²(C₁-C₆)alkyl, (C₁-C₅)alkyl(CHR²²)(C₁-C₆)alkyl, R²³(C₁-C₆)alkyl, or (C₁-C₅)alkyl(CHR²³)(C₁-C₆)alkyl; R²⁰ and R²¹ are each independently hydrogen, deuterium, (C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkyl; R²² is hydroxy, (C₁-C₆)acyloxy, (C₁-C₆)alkoxy, piperazino, (C₁-C₆)acylamino, (C₁-C₆)alkylthio, (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl, (C₆-C₁₀)arylsulfinyl, (C₁-C₆)alkylsulfoxyl, (C₆-C₁₀)arylsulfoxyl, amino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)acylpiperazino, (C₁-C₆)alkylpiperazino, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino, thiomorpholino, piperidino or pyrrolidino; R²³ is piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroarylpiperidyl or (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl; F, K and P are each independently oxygen, S(O)_(d), NR⁶ or CR⁷R⁸; Z is hydroxy, (C₁-C₆)alkoxy or NR¹⁷R¹⁸; d, m, g, w, and y are each independently is 0, 1 or 2; g, h and j are each independently 0 to 6; p and x are each independently is 0, 1, 2 or 3; with the proviso that when R⁴ is hydrogen, unsubstituted (C₁-C₆)alkyl or unsubstituted (C₃-C₁₀)cycloalkyl, R⁵ cannot be (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl; and R¹⁴ cannot be (C₂-C₉)heterocycloalkyl, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidinyl or (C₁-C₆)alkylpiperidinyl; with the proviso that the sp² and sp carbons of alkenyl or alkynyl cannot be substituted by hydroxy or amino; with the proviso that when R⁴ is hydrogen, R⁵ cannot be amino(C₁-C₆)alkyl, (C₁-C₆)alkyl, or (C₁-C₆)alkylamino(C₁-C₆)alkyl; with the proviso that both R⁴ and R⁵ cannot both be hydroxy(C₁-C₆)alkyl, and with the proviso that the (C₃-C₁₀)cycloalkyl group of R⁵ contains zero levels of unsaturation, alone or in combination with one or more additional agents which modulate a mammalian immune system or with antiinflammatory agents.
 12. A method for treating or preventing a disorder or condition selected from organ transplant rejection, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukemia and other autoimmune diseases in a mammal, including a human, comprising administering to said mammal an amount of a compound of the formula

or the pharmaceutically acceptable salt thereof; wherein R¹ is OR⁹, S(O)_(q)R⁹, or a group of the formula

R² and R³ are each independently hydrogen, deuterium, amino, halo, hydroxy, nitro, carboxy, (C₂-C₆)alkenyl, (C₁-C₆)alkynyl, (C₁-C₆)alkyl, or (C₁-C₆)alkoxy wherein the alkyl or alkoxy groups are optionally substituted by one to three groups selected from halo, hydroxy, carboxy, amino(C₁-C₆)alkylthio, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₅-C₉)heteroaryl, (C₂-C₉)heterocycloalkyl, (C₃-C₉)cycloalkyl or (C₆-C₁₀)aryl; or R² and R³ are each independently (C₇-C₁₀)cycloalkyl, (C₇-C₁₀)cycloalkoxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₆-C₁₀)arylamino, (C₁-C₆)alkylthio, (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl, (C₆-C₁₀)arylsulfinyl, (C₁-C₆)alkylsulfonyl, (C₆-C₁₀)arylsulfonyl, (C₁-C₆)acyl, (C₁-C₆)alkoxy-CO—NH—, (C₁-C₆)alkylamino-CO—, (C₅-C₉)heteroaryl, (C₂-C₉)heterocycloalkyl or (C₆-C₁₀)aryl wherein the heteroaryl, heterocycloalkyl and aryl groups are optionally substituted by one to three halo, (C₁-C₆)alkyl, (C₁-C₆)alkyl-CO—NH—, (C₁-C₆)alkoxy-CO—NH—, (C₁-C₆)alkyl-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH—(C₁-C₆)alkoxy, carboxy, carboxy(C₁-C₆)alkyl, carboxy(C₁-C₆)alkoxy, benzyloxycarbonyl(C₁-C₆)alkoxy, (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkoxy, (C₆-C₁₀)aryl, amino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxycarbonylamino, (C₆-C₁₀)aryl(C₁-C₆)alkoxycarbonylamino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, hydroxy, (C₁-C₆)alkoxy, (C₁-C₆)alkoxycarbonyl, (C₁-C₆)alkoxycarbonyl(C₁-C₆)alkyl, cyano, amino-CO—NH—, (C₁-C₆)alkylamino-CO—NH—, ((C₁-C₆)alkyl)₂amino-CO—NH—, (C₆-C₁₀)arylamino-CO—NH—, (C₅-C₉)heteroarylamino-CO—NH—, (C₁-C₆)alkylamino-CO—NH—(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino-CO—NH—(C₁-C₆)alkyl, (C₆-C₁₀)arylamino-CO—NH—(C₁-C₆)alkyl, (C₅-C₉)heteroarylamino-CO—NH—(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl, (C₁-C₆)alkylsulfonylamino, (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl, (C₆-C₁₀)arylsulfonylamino, (C₆-C₁₀)arylsulfonylamino(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonylamino, (C₁-C₆)alkylsulfonylamino(C₁-C₆)alkyl, (C₅-C₉)heteroaryl or (C₂-C₉)heterocycloalkyl; R⁴ is hydrogen, (C₁-C₆)alkyl, (C₂-C₆)alkenyl, or (C₂-C₆)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C₁-C₄)alkoxy, (C₁-C₆)acyloxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, cyano, nitro, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl or (C₁-C₆)acylamino; or R⁴ is (C₇-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C₁-C₆)acyloxy, (C₁-C₆)acylamino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, cyano, cyano(C₁-C₆)alkyl, trifluoromethyl(C₁-C₆)alkyl, nitro, nitro(C₁-C₆)alkyl or (C₁-C₆)acylamino, R⁵ is trifluoromethyl(C₁-C₆)alkyl, (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, or (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C₁-C₆)alkyl, (C₁-C₆)alkoxy, halo, (C₁-C₆)acyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro, cyano(C₁-C₆)alkyl, halo(C₁-C₆)alkyl, nitro(C₁-C₆)alkyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)acylamino, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, amino(C₁-C₆)acyl(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, R¹⁵R¹⁶N—CO—O—, R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl, (C₁-C₆)alkyl-S(O)_(m), R¹⁵R¹⁶NS(O)_(m), R¹⁵R¹⁶NS(O)_(m) (C₁-C₆)alkyl, R¹⁵S(O)_(m)R¹⁶N, or R¹⁵S(O)_(m)R¹⁶N(C₁-C₆)alkyl; or R⁵ is (C₃-C₁₀)cycloalkyl(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₂-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)alkyl, (C₂-C₆)alkenyl, or (C₂-C₆)alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by one to five cyano, nitro, halo, deuterium, hydroxy, carboxy, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁵ is R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or R⁵ is a group of the formula

or R⁵ is a group of the formula

R⁶ is hydrogen, (C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)alkyl(difluoromethylene), (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₁-C₆)alkoxy(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C_(10)aryl(C) ₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₂-C₆)alkyl, (C₁-C₆)acyloxy(C₂-C₆)alkyl, (C₁-C₆)alkoxy(C₂-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, R¹³CO(C₁-C₆)alkyl or R¹⁴(C₂-C₆)alkyl; R⁷ and R⁸ are each independently hydrogen, (C₁-C₆)alkyl, amino, hydroxy, (C₁-C₆)alkoxy, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)amino, (C₁-C₆)acylamino, (C₁-C₆)acyl(C₁-C₆)alkylamino, carboxy, (C₁-C₆)alkoxyacyl, (C₁-C₆)alkylaminoacyl, ((C₁-C₆)alkyl)₂aminoacyl, aminoacyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)alkyl(difluoromethylene), (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C_(10)aryl(C) ₁-C₆)alkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino(C₁-C₆)alkyl, R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or a group of the formula

R⁹ is trifluoromethyl(C₁-C₆)alkyl, (C₁-C₃)alkyl(difluoromethylene)(C₁-C₃)alkyl, or (C₃-C₁₀)cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five carboxy, cyano, amino, hydroxy, (C₁-C₆)alkoxy, halo, (C₁-C₆)alkyl S(O)_(m), R¹⁵R¹⁶NS(O)_(m), (C₁-C₆)acyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, (C₁-C₆)alkoxy-CO—NH, (C₁-C₆)alkylamino-CO—, R¹⁵R¹⁶N—CO—O—R¹⁵R¹⁶N—CO—(C₁-C₆)alkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₁-C₆)alkylamino, amino(C₁-C₆)alkyl, hydroxy(C₁-C₆)alkyl, (C₁-C₆)alkoxy(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, nitro, cyano(C₁-C₆)alkyl, nitro(C₁-C₆)alkyl, trifluoromethyl, trifluoromethyl(C₁-C₆)alkyl, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl, or ((C₁-C₆alkyl)₂amino(C₁-C₆)acyl; or R⁹ is (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, (C₃-C₁₀)cycloalkyl(C₁-C₆)alkyl, (C₁-C₆)acyloxy(C₁-C₆)alkyl, (C₂-C₆)alkoxy(C₁-C₆)alkyl, piperazinyl(C₁-C₆)alkyl, (C₁-C₆)acylamino(C₁-C₆)alkyl, (C₁-C₆)alkylthio(C₁-C₆)alkyl, (C₆-C₁₀)arylthio(C₁-C₆)alkyl, (C₁-C₆)alkylsulfinyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfinyl(C₁-C₆)alkyl, (C₁-C₆)alkylsulfonyl(C₁-C₆)alkyl, (C₆-C₁₀)arylsulfonyl(C₁-C₆)alkyl, amino(C₁-C₆)alkyl, (C₁-C₆)alkylamino(C₁-C₆)alkyl, ((C₁-C₆)alkyl)₂amino, or (C₁-C₆)alkyl wherein the alkyl group is optionally substituted by one to five cyano, nitro, hydroxy, carboxy, (C₁-C₆)acylamino, (C₁-C₆)alkoxy(C₁-C₆)acylamino, amino(C₁-C₆)acyl, (C₁-C₆)alkylamino(C₁-C₆)acyl or ((C₁-C₆)alkyl)₂amino(C₁-C₆)acyl; or R⁹ is R¹³CO(C₁-C₆)alkyl, R¹³CO(C₇-C₁₀)cycloalkyl, R¹⁴, R¹⁴(C₁-C₆)alkyl or R¹⁴(C₇-C₁₀)cycloalkyl; or R⁹ is a group of the formula

R¹³ is R²⁰O or R²⁰R²¹N; R¹⁴ is (C₂-C₉)heterocycloalkyl, (C₁-C₆)acylpiperazino, (C₆-C₁₀)arylpiperazino, (C₅-C₉)heteroarylpiperazino, (C₁-C₆)alkylpiperazino, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidyl, (C₁-C₆)alkylpiperidinyl, (C₆-C₁₀)arylpiperidyl(C₅-C₉)heteroarylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl or (C₁-C₆)acylpiperidyl; R¹⁵ and R¹⁶ are each independently hydrogen or (C₁-C₆)alkyl; R¹⁷ and R¹⁸ are each independently hydrogen, (C₁-C₆)alkyl, piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl, (C₅-C₉)heteroarylpiperidyl(C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl, (C₁-C₆)acylpiperidyl, (C₆-C₁₀)aryl, (C₅-C₉)heteroaryl, (C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₅-C₉)heteroaryl(C₁-C₆)alkyl, (C₆-C₁₀)aryl, (C₆-C₁₀)aryl(C₆-C₁₀)aryl(C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₆)cycloalkyl(C₁-C₆)alkyl, R²²(C₁-C₆)alkyl, (C₁-C₅)alkyl(CHR²²)(C₁-C₆)alkyl, R²³(C₁-C₆)alkyl, or (C₁-C₅)alkyl(CHR²³)(C₁-C₆)alkyl; R²⁰ and R²¹ are each independently hydrogen, deuterium, (C₁-C₆)alkyl, (C₆-C₁₀)aryl(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkyl; R²² is hydroxy, (C₁-C₆)acyloxy, (C₁-C₆)alkoxy, piperazino, (C₁-C₆)acylamino, (C₁-C₆)alkylthio, (C₆-C₁₀)arylthio, (C₁-C₆)alkylsulfinyl, (C₆-C₁₀)arylsulfinyl, (C₁-C₆)alkylsulfoxyl, (C₆-C₁₀)arylsulfoxyl, amino, (C₁-C₆)alkylamino, ((C₁-C₆)alkyl)₂amino, (C₁-C₆)acylpiperazino, (C₁-C₆)alkylpiperazino, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperazino, (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperazino, morpholino, thiomorpholino, piperidino or pyrrolidino; R²³ is piperidyl, (C₁-C₆)alkylpiperidyl, (C₆-C₁₀)arylpiperidyl, (C₆-C₁₀)aryl(C₁-C₆)alkylpiperidyl, (C₅-C₉)heteroarylpiperidyl or (C₅-C₉)heteroaryl(C₁-C₆)alkylpiperidyl; F, K and P are each independently oxygen, S(O)_(d), NR⁶ or CR⁷R⁸; Z is hydroxy, (C₁-C₆)alkoxy or NR¹⁷R¹⁸; d, m, q, w, and v are each independently is 0, 1 or 2; g, h and j are each independently 0 to 6; p and x are each independently is 0, 1, 2 or 3; with the proviso that when R⁴ is hydrogen, unsubstituted (C₁-C₆)alkyl or unsubstituted (C₃-C₁₀)cycloalkyl, R⁵ cannot be (C₆-C₁₀)aryl(C₁-C₆)alkoxy(C₁-C₆)alkyl or (C₅-C₉)heteroaryl(C₁-C₆)alkoxy(C₁-C₆)alkyl; and R¹⁴ cannot be (C₂-C₉)heterocycloalkyl, morpholino, thiomorpholino, piperidino, pyrrolidino, piperidinyl or (C₁-C₆)alkylpiperidinyl; with the proviso that the sp² and sp carbons of alkenyl or alkynyl cannot be substituted by hydroxy or amino; with the proviso that when R⁴ is hydrogen, R⁵ cannot be amino(C₁-C₆)alkyl, (C₁-C₆)alkyl, or (C₁-C₆)alkylamino(C₁-C₆)alkyl; with the proviso that both R⁴ and R⁵ cannot both be hydroxy(C₁-C₆)alkyl; and with the proviso that the (C₃-C₁₀)cycloalkyl group of R⁵ contains zero levels of unsaturation, alone or in combination with one or more additional agents which modulate a mammalian immune system or with antiinflammatory agents, effective in treating or preventing such disorders or conditions. 